Document Detail


Influence of hydrostatic pressure gradients on regulation of plasma volume after exercise.
MedLine Citation:
PMID:  9688745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The impact of posture on the immediate recovery of intravascular fluid and protein after intense exercise was determined in 14 volunteers. Forces which govern fluid and protein movement in muscle interstitial fluid pressure (PISF), interstitial colloid osmotic pressure (COPi), and plasma colloid osmotic pressure (COPp) were measured before and after exercise in the supine or upright position. During exercise, plasma volume (PV) decreased by 5.7 +/- 0.7 and 7. 0 +/- 0.5 ml/kg body weight in the supine and upright posture, respectively. During recovery, PV returned to its baseline value within 30 min regardless of posture. PV fell below this level by 60 and 120 min in the supine and upright posture, respectively (P < 0. 05). Maintenance of PV in the upright position was associated with a decrease in systolic blood pressure, an increase in COPp (from 25 +/- 1 to 27 +/- 1 mmHg; P < 0.05), and an increase in PISF (from 5 +/- 1 to 6 +/- 2 mmHg), whereas COPi was unchanged. Increased PISF indicates that the hydrostatic pressure gradient favors fluid movement into the vascular space. However, retention of the recaptured fluid in the plasma is promoted only in the upright posture because of increased COPp.
Authors:
G W Mack; R Yang; A R Hargens; K Nagashima; A Haskell
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  85     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-03     Completed Date:  1998-09-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  667-75     Citation Subset:  IM; S    
Affiliation:
John B. Pierce Laboratory and Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06519, USA. mack@jbpierce.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Anaerobic Threshold / physiology
Blood Pressure / physiology
Colloids
Exercise / physiology*
Female
Heart Rate / physiology
Humans
Hydrostatic Pressure*
Lung / metabolism,  physiology
Male
Oxygen Consumption / physiology
Plasma / chemistry,  metabolism
Plasma Volume / physiology*
Posture / physiology
Grant Support
ID/Acronym/Agency:
HL-20634/HL/NHLBI NIH HHS; HL-39818/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Colloids
Investigator
Investigator/Affiliation:
G W Mack / Yale U, New Haven, CT; A R Hargens / ARC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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