| Influence of hydrogenated fat and butter on CVD risk factors: remnant-like particles, glucose and insulin, blood pressure and C-reactive protein. | |
| | |
MedLine Citation:
|
PMID: 14642411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dietary trans fatty acids/partially-hydrogenated fat has been associated with increased risk of developing cardiovascular disease (CVD), possibly greater than predicted from changes in lipoprotein levels. To explore this issue further potential risk factors were assessed in subjects provided with each of six diets in randomized order containing as the major source of fat: soybean oil, semi-liquid margarine, soft margarine, shortening, traditional stick margarine or butter. Plasma fatty acid profiles reflected diet, with triglyceride and phospholipid subfractions affected to a greater extent than cholesteryl ester. Non-fasting LDL-cholesterol levels were 144+/-27, 141+/-27, 146+/-26, 148+/-30, 151+/-29 and 165+/-31 mg/dl (P<0.001) and total cholesterol/HDL-cholesterol ratios were 5.50+/-1.25, 5.54+/-1.50, 5.69+/-1.29, 5.82+/-1.40, 6.11+/-1.30 and 5.94+/-1.43 (P=0.011), respectively, whereas other lipoprotein levels were not significantly different. Remnant-like particles levels were unaffected by dietary fat, either in the fasting or non-fasting state. Differences in fasting insulin and glucose levels were small and would not be predicted to have a large impact on glucose homeostasis. There was no significant effect of dietary fat type on C-reactive protein levels or blood pressure. These data suggest that, as previously demonstrated, the major CVD risk factor adversely affected by dietary trans fatty acids/partially-hydrogenated fat is LDL-cholesterol levels and total cholesterol/HDL-cholesterol ratios. |
| | |
Authors:
|
Alice H Lichtenstein; Arja T Erkkilä; Benoît Lamarche; Ursula S Schwab; Susan M Jalbert; Lynne M Ausman |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Atherosclerosis Volume: 171 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2003 Nov |
Date Detail:
|
Created Date: 2003-12-03 Completed Date: 2004-05-19 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 97-107 Citation Subset: IM |
Affiliation:
|
Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. alice.lichtenstein@tufts.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Biological Markers / blood Blood Glucose / drug effects, metabolism Blood Pressure / drug effects Boston Butter C-Reactive Protein / drug effects, metabolism Cardiovascular Diseases / blood, epidemiology*, etiology* Cholesterol, HDL / blood, drug effects Cholesterol, LDL / blood, drug effects Cholesterol, VLDL / blood, drug effects Dietary Fats / administration & dosage, blood* Dose-Response Relationship, Drug Double-Blind Method Fasting / blood Fatty Acids / administration & dosage, blood Fatty Acids, Unsaturated / administration & dosage, blood Female Humans Hydrogenation Insulin / blood Male Margarine Middle Aged Phospholipids / blood Predictive Value of Tests Risk Factors Sex Factors Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
|
HL54727/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 0/Triglycerides; 11061-68-0/Insulin; 8029-34-3/Butter; 8029-82-1/Margarine; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiatherothrombotic effects of nicotinic acid.
Next Document: Normalization of daytime triglyceridemia by simvastatin in fasting normotriglyceridemic patients wit...