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Influence of humic acid derived from composted wastes of Nigeria origin on oxidative and antioxidant status of African mud catfish (Clarias gariepinus).
MedLine Citation:
PMID:  21313906     Owner:  NLM     Status:  In-Process    
The utilization of organic fertilizer, a product of composted organic wastes, is being advocated in Nigeria as a solid waste management alternative. The application of such products near surface water could increase organic matter load of the aquatic environment, thus increasing the humic substance concentration that influence metal speciation and bioavailability in water. In this study, Humic Acid (HA), a major humic substance fraction, derived from composted organic wastes of Nigeria origin was evaluated for effects on the oxidative and antioxidant status of African Mud Catfish (Clarias gariepinus) exposed to different HA (100, 250, 500 and 1000 mg L(-1)) concentrations in static water culture. Lipid peroxidation was estimated via malondialdehyde (MDA) using thiobarbituric acid assay while oxidative stress was assessed spectrophotometrically, via superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) using standard enzymatic assay techniques. Results showed that treatments increased MDA by 20 to 70% but decreased SOD, CAT and GSH by 10 to 42.56%, 43.62 to 64.09% and 9.84 to 67.68%, respectively. Negative coefficient (r) was obtained for CAT (r = - 0.491; p > 0.10), GSH (r = - 0.551; p > 0.10) versus HA concentration but correlation was positive for MDA (r = 0.998; p = 0.012) and the latter. Study revealed humic acid-mediated oxidative stress and lipid oxidation in the fish. The adverse impact was a function of humic acid concentration and an assessment of heavy metal-humic acid mixture effect on the oxidative and antioxidant status of fresh water fish is recommended.
I M Adekunle; O R Ajuwon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pakistan journal of biological sciences: PJBS     Volume:  13     ISSN:  1028-8880     ISO Abbreviation:  Pak. J. Biol. Sci.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2011-02-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247723     Medline TA:  Pak J Biol Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  821-7     Citation Subset:  IM    
Department of Environmental Management and Toxicology, University of Agriculture, P.M.B. 2240, Abeokuta, Nigeria.
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