Document Detail


Influence of hormones on N-(4-hydroxyphenyl) retinamide inhibition of 7,12-dimethylbenz[alpha]anthracene transformation of mammary cells in organ culture.
MedLine Citation:
PMID:  6217889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Influence of estrogen and progesterone on the inhibitory action of N-(4-hydroxyphenyl) retinamide (4-HPR) was examined during the promotional stage of 7,12-dimethylbenz[alpha]anthracene (DMBA) transformation of the epithelial cells in culture of the whole mammary organs of BALB/c mice. In medium containing insulin, prolactin, hydrocortisone, and aldosterone, 4-HPR caused 68% inhibition of transformation as determined by the presence of nodule-like alveolar structures in the glands exposed to DMBA in vitro. Addition of estrogen and progesterone to the medium reduced this pronounced inhibitory action of 4-HPR to only 15%. While the medium containing insulin, prolactin, growth hormone, estrogen and progesterone was highly conducive to DMBA transformation, 4-HPR inhibition of transformation was limited to only 21%. The antagonistic action of the ovarian steroid hormones was present also at the level of frequency of nodule-like alveolar lesions (NLAL) per gland. Although both ovarian hormones reduced the inhibitory action of 4-HPR, on mammary cell transformation, the antagonistic action of estrogen was noticeably more pronounced.
Authors:
M Chatterjee; M R Banerjee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer letters     Volume:  16     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  239-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
9,10-Dimethyl-1,2-benzanthracene / pharmacology*
Animals
Benz(a)Anthracenes / pharmacology*
Castration
Cell Transformation, Neoplastic / drug effects*
Estrogens / pharmacology
Female
Fenretinide
Hormones / pharmacology*
Mammary Glands, Animal / drug effects*,  pathology
Mammary Neoplasms, Experimental / chemically induced
Mice
Mice, Inbred BALB C
Organ Culture Techniques
Progesterone / pharmacology
Tretinoin / analogs & derivatives*,  pharmacology
Grant Support
ID/Acronym/Agency:
CA11058/CA/NCI NIH HHS; CA25304/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Benz(a)Anthracenes; 0/Estrogens; 0/Hormones; 302-79-4/Tretinoin; 57-83-0/Progesterone; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 65646-68-6/Fenretinide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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