Document Detail

Influence of honey on the gastrointestinal metabolism and disposition of glycyrrhizin and glycyrrhetic acid in rabbits.
MedLine Citation:
PMID:  11824564     Owner:  NLM     Status:  MEDLINE    
To investigate the effects of honey on the pharmacokinetics of glycyrrhizin and glycyrrhetic acid, administration of glycyrrhizin or glycyrrhetic acid with and without honey was carried out in rabbits in a randomized crossover design. An in vitro study using rabbit fecal flora was employed to elucidate the mechanism of the interaction. HPLC methods were used for the determination of glycyrrhizin, glycyrrhetic acid and 3-dehydroglycyrrhetic acid concentrations in serum and feces. Paired and unpaired Student's t-tests were used for statistical comparisons for in vivo and in vitro studies, respectively. Our study indicated that the area under the curve (AUC0-t) of glycyrrhetic acid was significantly enhanced by 53% when honey was concomitantly given with glycyrrhizin, whereas that of glycyrrhizin was not significantly altered. Nevertheless, lack of effect was observed when honey was concurrently given with glycyrrhetic acid. Fecal study indicated that both the hydrolysis of glycyrrhizin to glycyrrhetic acid and subsequent oxidation of glycyrrhetic acid to 3-dehydroglycyrrhetic acid were significantly affected in the presence of honey to result in more glycyrrhetic acid available for absorption. It could be concluded that honey significantly affected the gastrointestinal metabolism of glycyrrhizin and resulted in the increased glycyrrhetic acid exposure. Therefore, honey might enhance the efficacy and adverse effects of glycyrrhizin.
Hui Ching; Yu-Chi Hou; Su-Lan Hsiu; Shang-Yuan Tsai; Pei-Dawn Lee Chao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  25     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-04     Completed Date:  2002-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, ROC.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
Carbohydrate Sequence
Chromatography, High Pressure Liquid
Digestive System / metabolism*
Feces / microbiology
Glycyrrhetinic Acid / pharmacokinetics*
Intestinal Absorption / drug effects
Molecular Sequence Data
Spectrophotometry, Ultraviolet
Tissue Distribution
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 471-53-4/Glycyrrhetinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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