Document Detail

Influence of a history of smoking on short term (six month) clinical and angiographic outcome after successful coronary angioplasty.
MedLine Citation:
PMID:  10956296     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the influence of smoking on restenosis after coronary angioplasty. DESIGN AND PATIENTS: The incidence of smoking on restenosis was investigated in 2948 patients. They were prospectively enrolled in four major restenosis trials in which quantitative angiography was used before and immediately after successful angioplasty and again at six months. RESULTS: Within the study population there were 530 current smokers, 1690 ex-smokers, and 728 non-smokers. Smokers were more likely to be men (85.9% v 87. 5% v 65.3%, current v ex- v non-, p < 0.001), to be younger (54.0 (9. 0) v 57.0 (9.1) v 59.9 (9.4) years, p < 0.001), to have peripheral vascular disease (7.2% v 5.5% v 2.3%, p < 0.001), and have sustained a previous myocardial infarction (42.9% v 43.9% v 37.9%, p = 0.022), but were less likely to be diabetic (9.1% v 9.5% v 12.6%, p = 0.043) or hypertensive (24.9% v 29.3% v 37.2, p < 0.001). There was no significant difference in the categorical restenosis rate (> 50% diameter stenosis) at six months (35.28% v 35.33% v 37.09%, current v ex- v non-), or the absolute loss (0.29 (0.54) v 0.33 (0.52) v 0. 35 (0.55) mm, respectively; p = 0.172). CONCLUSIONS: Although smokers have a lower incidence of known predisposing risk factors for atherosclerosis, they require coronary intervention almost six years earlier than non-smokers and three years earlier than ex-smokers. Once they undergo successful coronary angioplasty, there appears to be no evidence that smoking influences their short term (six month) outcome, but because of the known long term effects of smoking, patients should still be encouraged to discontinue the habit.
A G Violaris; A Thury; E Regar; R Melkert; P W Serruys
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  84     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-09-19     Completed Date:  2000-09-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-306     Citation Subset:  AIM; IM    
Academic Cardiology Unit, St Mary's Hospital, London W2, UK.
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MeSH Terms
Age Factors
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Angiography
Coronary Disease / radiography,  therapy*
Disease-Free Survival
Follow-Up Studies
Middle Aged
Prospective Studies
Risk Factors
Smoking / adverse effects*
Statistics as Topic
Time Factors
Comment In:
Heart. 2000 Sep;84(3):233-4   [PMID:  10956278 ]

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