Document Detail


Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices.
MedLine Citation:
PMID:  23035077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Whole-cell patch-clamp recordings and high-resolution 3D morphometric analyses of layer 3 pyramidal neurons in in vitro slices of monkey primary visual cortex (V1) and dorsolateral granular prefrontal cortex (dlPFC) revealed that neurons in these two brain areas possess highly distinctive structural and functional properties. Area V1 pyramidal neurons are much smaller than dlPFC neurons, with significantly less extensive dendritic arbors and far fewer dendritic spines. Relative to dlPFC neurons, V1 neurons have a significantly higher input resistance, depolarized resting membrane potential, and higher action potential (AP) firing rates. Most V1 neurons exhibit both phasic and regular-spiking tonic AP firing patterns, while dlPFC neurons exhibit only tonic firing. Spontaneous postsynaptic currents are lower in amplitude and have faster kinetics in V1 than in dlPFC neurons, but are no different in frequency. Three-dimensional reconstructions of V1 and dlPFC neurons were incorporated into computational models containing Hodgkin-Huxley and AMPA receptor and GABA(A) receptor gated channels. Morphology alone largely accounted for observed passive physiological properties, but led to AP firing rates that differed more than observed empirically, and to synaptic responses that opposed empirical results. Accordingly, modeling predicts that active channel conductances differ between V1 and dlPFC neurons. The unique features of V1 and dlPFC neurons are likely fundamental determinants of area-specific network behavior. The compact electrotonic arbor and increased excitability of V1 neurons support the rapid signal integration required for early processing of visual information. The greater connectivity and dendritic complexity of dlPFC neurons likely support higher level cognitive functions including working memory and planning.
Authors:
Joseph M Amatrudo; Christina M Weaver; Johanna L Crimins; Patrick R Hof; Douglas L Rosene; Jennifer I Luebke
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  32     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  2013-01-17     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13644-60     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Dendritic Spines / physiology,  ultrastructure
Excitatory Postsynaptic Potentials / physiology
Female
Inhibitory Postsynaptic Potentials / physiology
Macaca mulatta
Male
Microscopy, Confocal
Models, Neurological
Neurons / physiology*,  ultrastructure
Organ Specificity
Patch-Clamp Techniques
Prefrontal Cortex / cytology,  physiology*
Pyramidal Cells / physiology*
Synaptic Transmission
Visual Cortex / cytology,  physiology*
Grant Support
ID/Acronym/Agency:
P01 AG00001/AG/NIA NIH HHS; R01 AG025062/AG/NIA NIH HHS; R01 AG035071/AG/NIA NIH HHS; R01 AG035071/AG/NIA NIH HHS; RR00165/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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