| Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. | |
| | |
MedLine Citation:
|
PMID: 23035077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Whole-cell patch-clamp recordings and high-resolution 3D morphometric analyses of layer 3 pyramidal neurons in in vitro slices of monkey primary visual cortex (V1) and dorsolateral granular prefrontal cortex (dlPFC) revealed that neurons in these two brain areas possess highly distinctive structural and functional properties. Area V1 pyramidal neurons are much smaller than dlPFC neurons, with significantly less extensive dendritic arbors and far fewer dendritic spines. Relative to dlPFC neurons, V1 neurons have a significantly higher input resistance, depolarized resting membrane potential, and higher action potential (AP) firing rates. Most V1 neurons exhibit both phasic and regular-spiking tonic AP firing patterns, while dlPFC neurons exhibit only tonic firing. Spontaneous postsynaptic currents are lower in amplitude and have faster kinetics in V1 than in dlPFC neurons, but are no different in frequency. Three-dimensional reconstructions of V1 and dlPFC neurons were incorporated into computational models containing Hodgkin-Huxley and AMPA receptor and GABA(A) receptor gated channels. Morphology alone largely accounted for observed passive physiological properties, but led to AP firing rates that differed more than observed empirically, and to synaptic responses that opposed empirical results. Accordingly, modeling predicts that active channel conductances differ between V1 and dlPFC neurons. The unique features of V1 and dlPFC neurons are likely fundamental determinants of area-specific network behavior. The compact electrotonic arbor and increased excitability of V1 neurons support the rapid signal integration required for early processing of visual information. The greater connectivity and dendritic complexity of dlPFC neurons likely support higher level cognitive functions including working memory and planning. |
| | |
Authors:
|
Joseph M Amatrudo; Christina M Weaver; Johanna L Crimins; Patrick R Hof; Douglas L Rosene; Jennifer I Luebke |
Related Documents
:
|
23057747 - Line-1 retrotransposition in the nervous system. 23104007 - Inhibition of rna lariat debranching enzyme suppresses tdp-43 toxicity in als disease m... 23637167 - Phox2b-expressing retrotrapezoid neurons are intrinsically responsive to h+ and co2. 22774807 - The new iminothiadiazole derivative vp1.14 ameliorates hippocampal damage after an exci... 9507957 - Reorganization of the somatosensory cortex after amputation of the index finger. 19431267 - State-dependent computation using coupled recurrent networks. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 32 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-04 Completed Date: 2013-01-17 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 13644-60 Citation Subset: IM |
Affiliation:
|
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials Animals Dendritic Spines / physiology, ultrastructure Excitatory Postsynaptic Potentials / physiology Female Inhibitory Postsynaptic Potentials / physiology Macaca mulatta Male Microscopy, Confocal Models, Neurological Neurons / physiology*, ultrastructure Organ Specificity Patch-Clamp Techniques Prefrontal Cortex / cytology, physiology* Pyramidal Cells / physiology* Synaptic Transmission Visual Cortex / cytology, physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
P01 AG00001/AG/NIA NIH HHS; R01 AG025062/AG/NIA NIH HHS; R01 AG035071/AG/NIA NIH HHS; RR00165/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.
Next Document: Light-mediated control of rhodopsin movement in mosquito photoreceptors.