Document Detail


Influence of a high-fat meal on the absorption of morphine from oral solutions.
MedLine Citation:
PMID:  2791448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of a high-fat meal on blood morphine concentrations after the administration of a morphine solution (50 mg dose) was studied in 12 patients with chronic pain. The oral morphine dose was administered in a total volume of 200 ml to patients either immediately after food intake or while in the fasting state. There was a 34% increase in the area under the curve (AUC) when morphine was administered immediately after food when compared with the fasting state (p less than 0.02). However, there was no significant difference between the maximum blood morphine concentration (Cmax) or the time to maximum concentration (tmax) between the two treatment regimens. The shape of the blood morphine concentration-time curve was consistently altered in the fed patients compared with patients who were in the fasting state, inasmuch as the blood morphine concentrations were maintained at a higher level from 240 to 600 minutes after the dose when the morphine was administered with food (p less than 0.02). It is suggested that morphine concentrations are maintained at higher levels, possibly resulting in more prolonged pain relief, when morphine is administered with food compared with the same dose administered to patients who are in the fasting state.
Authors:
G K Gourlay; J L Plummer; D A Cherry; J A Foate; M J Cousins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  46     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-22     Completed Date:  1989-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  463-8     Citation Subset:  AIM; IM    
Affiliation:
Pain Management Unit, Flinders Medical Centre, Bedford Park, South Australia.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Dietary Fats / pharmacology*
Fasting
Female
Humans
Intestinal Absorption / drug effects*
Male
Middle Aged
Morphine / administration & dosage,  blood,  pharmacokinetics*,  therapeutic use
Pain / drug therapy*
Chemical
Reg. No./Substance:
0/Dietary Fats; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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