| Influence of a high-fat meal on the absorption of morphine from oral solutions. | |
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MedLine Citation:
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PMID: 2791448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of a high-fat meal on blood morphine concentrations after the administration of a morphine solution (50 mg dose) was studied in 12 patients with chronic pain. The oral morphine dose was administered in a total volume of 200 ml to patients either immediately after food intake or while in the fasting state. There was a 34% increase in the area under the curve (AUC) when morphine was administered immediately after food when compared with the fasting state (p less than 0.02). However, there was no significant difference between the maximum blood morphine concentration (Cmax) or the time to maximum concentration (tmax) between the two treatment regimens. The shape of the blood morphine concentration-time curve was consistently altered in the fed patients compared with patients who were in the fasting state, inasmuch as the blood morphine concentrations were maintained at a higher level from 240 to 600 minutes after the dose when the morphine was administered with food (p less than 0.02). It is suggested that morphine concentrations are maintained at higher levels, possibly resulting in more prolonged pain relief, when morphine is administered with food compared with the same dose administered to patients who are in the fasting state. |
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Authors:
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G K Gourlay; J L Plummer; D A Cherry; J A Foate; M J Cousins |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 46 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1989-11-22 Completed Date: 1989-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 463-8 Citation Subset: AIM; IM |
Affiliation:
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Pain Management Unit, Flinders Medical Centre, Bedford Park, South Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Dietary Fats / pharmacology* Fasting Female Humans Intestinal Absorption / drug effects* Male Middle Aged Morphine / administration & dosage, blood, pharmacokinetics*, therapeutic use Pain / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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