Document Detail


Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats.
MedLine Citation:
PMID:  20962915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have suggested that high-fat diets adversely affect bone development. However, these studies included other dietary manipulations, including low calcium, folic acid, and fibre, and (or) high sucrose or cholesterol, and did not directly compare several common sources of dietary fat. Thus, the overall objective of this study was to investigate the effect of high-fat diets that differ in fat quality, representing diets high in saturated fatty acids (SFA), n-3 polyunsaturated fatty acids (PUFA), or n-6 PUFA, on femur bone mineral density (BMD), strength, and fatty acid composition. Forty-day-old male Sprague-Dawley rats were maintained for 65 days on high-fat diets (20% by weight), containing coconut oil (SFA; n = 10), flaxseed oil (n-3 PUFA; n = 10), or safflower oil (n-6 PUFA; n = 11). Chow-fed rats (n = 10), at 105 days of age, were included to represent animals on a control diet. Rats fed high-fat diets had higher body weights than the chow-fed rats (p < 0.001). Among all high-fat groups, there were no differences in femur BMD (p > 0.05) or biomechanical strength properties (p > 0.05). Femurs of groups fed either the high n-3 or high n-6 PUFA diets were stronger (as measured by peak load) than those of the chow-fed group, after adjustment for significant differences in body weight (p = 0.001). As expected, the femur fatty acid profile reflected the fatty acid composition of the diet consumed. These results suggest that high-fat diets, containing high levels of PUFA in the form of flaxseed or safflower oil, have a positive effect on bone strength when fed to male rats 6 to 15 weeks of age.
Authors:
Beatrice Y Lau; Val Andrew Fajardo; Lauren McMeekin; Sandra M Sacco; Wendy E Ward; Brian D Roy; Sandra J Peters; Paul J Leblanc
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  35     ISSN:  1715-5312     ISO Abbreviation:  Appl Physiol Nutr Metab     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  598-606     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animals
Biomechanics
Bone Density / physiology*
Dietary Fats / pharmacology*
Femur / physiology*
Linoleic Acid / metabolism,  pharmacology*
Linseed Oil / pharmacology
Male
Plant Oils / pharmacology
Rats
Rats, Sprague-Dawley
Safflower Oil / pharmacology
Weight-Bearing / physiology
alpha-Linolenic Acid / metabolism,  pharmacology*
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Plant Oils; 2197-37-7/Linoleic Acid; 463-40-1/alpha-Linolenic Acid; 8001-23-8/Safflower Oil; 8001-26-1/Linseed Oil; 8001-31-8/coconut oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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