Document Detail


Influence of hemoglobin E trait on the severity of Falciparum malaria.
MedLine Citation:
PMID:  9841856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine if hemoglobin E trait influences the course of acute malaria, adults hospitalized for the treatment of symptomatic infection with Plasmodium falciparum were studied retrospectively. Forty-two patients with hemoglobin E trait were compared with 175 reference subjects who did not have hemoglobin E, beta-thalassemia, glucose-6-phosphate dehydrogenase deficiency, or alpha-thalassemia. One patient (2.4%) with hemoglobin E trait had a severe complication of malaria by World Health Organization criteria (cerebral malaria), while 32 subjects in the reference group (18.3%) had one or more severe complications: cerebral malaria (n=18), hyperparasitemia (n=16), renal failure (n=10), and severe anemia (n=1) (P=.044 after adjustment for ethnic categories). The estimated odds of severe complications in the reference subjects were 6.9 times the odds in patients with hemoglobin E trait (95% confidence interval, 1.2-146. 4). These results suggest that hemoglobin E trait may ameliorate the course of acute falciparum malaria.
Authors:
R Hutagalung; P Wilairatana; S Looareesuwan; G M Brittenham; M Aikawa; V R Gordeuk
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  179     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-03     Completed Date:  1999-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-6     Citation Subset:  AIM; IM    
Affiliation:
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Case-Control Studies
Female
Hemoglobin E / genetics*
Humans
Malaria, Cerebral / blood,  genetics
Malaria, Falciparum / blood*,  complications,  genetics*
Male
Middle Aged
Retrospective Studies
Risk Factors
Thailand
Grant Support
ID/Acronym/Agency:
AI-35827/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
9034-61-1/Hemoglobin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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