| Influence of hemoglobin E trait on the severity of Falciparum malaria. | |
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MedLine Citation:
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PMID: 9841856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine if hemoglobin E trait influences the course of acute malaria, adults hospitalized for the treatment of symptomatic infection with Plasmodium falciparum were studied retrospectively. Forty-two patients with hemoglobin E trait were compared with 175 reference subjects who did not have hemoglobin E, beta-thalassemia, glucose-6-phosphate dehydrogenase deficiency, or alpha-thalassemia. One patient (2.4%) with hemoglobin E trait had a severe complication of malaria by World Health Organization criteria (cerebral malaria), while 32 subjects in the reference group (18.3%) had one or more severe complications: cerebral malaria (n=18), hyperparasitemia (n=16), renal failure (n=10), and severe anemia (n=1) (P=.044 after adjustment for ethnic categories). The estimated odds of severe complications in the reference subjects were 6.9 times the odds in patients with hemoglobin E trait (95% confidence interval, 1.2-146. 4). These results suggest that hemoglobin E trait may ameliorate the course of acute falciparum malaria. |
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Authors:
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R Hutagalung; P Wilairatana; S Looareesuwan; G M Brittenham; M Aikawa; V R Gordeuk |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 179 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-02-03 Completed Date: 1999-02-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 283-6 Citation Subset: AIM; IM |
Affiliation:
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Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Case-Control Studies Female Hemoglobin E / genetics* Humans Malaria, Cerebral / blood, genetics Malaria, Falciparum / blood*, complications, genetics* Male Middle Aged Retrospective Studies Risk Factors Thailand |
| Grant Support | |
ID/Acronym/Agency:
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AI-35827/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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9034-61-1/Hemoglobin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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