Document Detail

Influence of hemoglobin E trait on the severity of Falciparum malaria.
MedLine Citation:
PMID:  9841856     Owner:  NLM     Status:  MEDLINE    
To determine if hemoglobin E trait influences the course of acute malaria, adults hospitalized for the treatment of symptomatic infection with Plasmodium falciparum were studied retrospectively. Forty-two patients with hemoglobin E trait were compared with 175 reference subjects who did not have hemoglobin E, beta-thalassemia, glucose-6-phosphate dehydrogenase deficiency, or alpha-thalassemia. One patient (2.4%) with hemoglobin E trait had a severe complication of malaria by World Health Organization criteria (cerebral malaria), while 32 subjects in the reference group (18.3%) had one or more severe complications: cerebral malaria (n=18), hyperparasitemia (n=16), renal failure (n=10), and severe anemia (n=1) (P=.044 after adjustment for ethnic categories). The estimated odds of severe complications in the reference subjects were 6.9 times the odds in patients with hemoglobin E trait (95% confidence interval, 1.2-146. 4). These results suggest that hemoglobin E trait may ameliorate the course of acute falciparum malaria.
R Hutagalung; P Wilairatana; S Looareesuwan; G M Brittenham; M Aikawa; V R Gordeuk
Related Documents :
11964276 - Moyamoya syndrome in childhood sickle cell disease: a predictive factor for recurrent c...
17939316 - Sickle cell anaemia: is it a cause for secondary osteoporosis?
1814876 - Haemorheological treatment of painful sickle cell crises. use of pentoxifylline.
11502666 - Plastic bronchitis and the role of bronchoscopy in the acute chest syndrome of sickle c...
15829156 - The trigemino-cervical reflex in patients with trigeminal neuralgia.
12503186 - Amelioration of prolidase deficiency in fibroblasts using adenovirus mediated gene tran...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  179     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-03     Completed Date:  1999-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-6     Citation Subset:  AIM; IM    
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Case-Control Studies
Hemoglobin E / genetics*
Malaria, Cerebral / blood,  genetics
Malaria, Falciparum / blood*,  complications,  genetics*
Middle Aged
Retrospective Studies
Risk Factors
Grant Support
Reg. No./Substance:
9034-61-1/Hemoglobin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A low interleukin-10 tumor necrosis factor-alpha ratio is associated with malaria anemia in children...
Next Document:  Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor prom...