| Influence of head-down bed rest on the circadian rhythms of hormones and electrolytes involved in hydroelectrolytic regulation. | |
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MedLine Citation:
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PMID: 11513324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated in six men the impact of a 17-day head-down bed rest (HDBR) on the circadian rhythms of the hormones and electrolytes involved in hydroelectrolytic regulation. This HDBR study was designed to mimic an actual spaceflight. Urine samples were collected at each voiding before, during and after HDBR. Urinary excretion of aldosterone, arginine vasopressin (AVP), cyclic guanosine monophosphate (cGMP), cortisol, electrolytes (Na+ and K+) and creatinine were determined. HDBR resulted in a significant reduction of body mass (P < 0.01) and of caloric intake [mean (SEM) 2,778 (37) kcal.24 h(-1) to 2,450 (36) kcal.24 h(-1), where 1 kcal.h(-1) = 1.163 J.s(-1); P< 0.01]. There was a significant increase in diastolic blood pressure [71.8 (0.7) mmHg vs 75.6 (0.91) mmHg], with no significant changes in either systolic blood pressure or heart rate. The nocturnal hormonal decrease of aldosterone was clearly evident only before and after HDBR, but the day/night difference did not appear during HDBR. The rhythm of K+ excretion was unchanged during HDBR, whereas for Na+ excretion, a large decrease was shown during the night as compared to the day. The circadian rhythm of cortisol persisted. These data suggest that exposure to a 17-day HDBR could induce an exaggeration of the amplitude of the Na+ rhythm and abolition of the aldosterone rhythm. |
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Authors:
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C Millet; M A Custaud; A M Allevard; M Zaouali-Ajina; T H Monk; S B Arnaud; B Claustrat; C Gharib; G Gauquelin-Koch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: European journal of applied physiology Volume: 85 ISSN: 1439-6319 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-08-21 Completed Date: 2002-01-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 74-81 Citation Subset: IM; S |
Affiliation:
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Laboratoire de Physiologie de l'Environnement (GIP Exercise and EA 645), Faculté de Médecine, Lyon Grange-Blanche, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / urine* Arginine Vasopressin / urine Blood Pressure / physiology Body Mass Index Circadian Rhythm / physiology* Creatinine / urine Cyclic GMP / urine Diuresis / physiology Energy Intake / physiology Head-Down Tilt Heart Rate / physiology Humans Hydrocortisone / urine Male Middle Aged Posture / physiology Potassium / urine* Sodium / urine* Stress, Physiological / physiopathology Water-Electrolyte Balance / physiology* |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium; 7665-99-8/Cyclic GMP |
| Investigator | |
Investigator/Affiliation:
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T H Monk / U Pittsburgh Med Ctr, PA; S B Arnaud / ARC |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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