|Influence of haemodialysis and left ventricular failure on peripheral A(2A) adenosine receptor expression.|
|PMID: 17132707 Owner: NLM Status: MEDLINE|
|BACKGROUND: Haemodialysis (HD) sometimes accelerates left ventricular failure (LVF). As adenosine (ADO) is strongly implicated in cardiovascular functions, particularly via A(2A) receptor activation and as changes of peripheral A(2A) receptors mirror changes occurring in the cardiovascular system, we examined the influence of HD and LVF on both ADO plasma concentration and the expression of A(2A) receptors (i.e. Bmax, K(D) and mRNA amount) of peripheral blood mononuclear cells. METHODS: This cross-sectional study included 61 chronic renal failure (CRF) patients: 41 without LVF (24 haemodialysed and 17 undialysed) and 20 with LVF (9 haemodialysed and 11 undialysed). Ten LVF patients without CRF and 10 healthy subjects were also examined. RESULTS: (i) Bmax values of CRF patients without LVF were significantly decreased in undialysed patients compared with haemodialysed patients, and compared with controls (69 +/- 25 vs 98 +/- 33 vs 180 +/- 60 fmol/mg of protein, P < 0.05). Bmax values of CRF patients with LVF were lower in undialysed patients than in haemodialysed patients (60 +/- 27 vs 101 +/- 27 fmol/mg of protein, P < 0.05). Bmax values of LVF patients without CRF were lower than in controls (51 +/- 19 vs 180 +/- 60 fmol/mg of protein). (ii) A(2A) mRNA expression was increased in haemodialysed patients compared with controls (20.2 +/- 0.75 vs 17.6 +/- 1.3, P < 0.05). (iii) ADO plasma levels were high in haemodialysed patients and further increased during the HD sessions. CONCLUSION: The number of A(2A) receptors was decreased by CRF with or without LVF. However, this decrease was less important in haemodialysed patients. The changes in peripheral A(2A) receptor expression suggest a significant inflammatory response to HD and heart or kidney failure. Whether these changes do reflect alterations in cardiomyocytes needs further investigation.|
|Louis Carrega; Emmanuel Fenouillet; Philippe Giaime; Annie Charavil; Laurence Mercier; Victoria Gerolami; Jean-Louis Berge-Lefranc; Yvon Berland; Jean Ruf; Alain Saadjian; Bertrand Dussol; Regis Guieu|
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|Type: Journal Article Date: 2006-11-28|
|Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 22 ISSN: 0931-0509 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2007 Mar|
|Created Date: 2007-02-22 Completed Date: 2007-05-01 Revised Date: 2007-11-15|
Medline Journal Info:
|Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England|
|Languages: eng Pagination: 851-6 Citation Subset: IM|
|FRE2738 CNRS/Université de la Méditerranée, Faculté de Médecine Nord, Bd P. Dramard, 13015 Marseille, France.|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Biological Markers / blood
Blood Urea Nitrogen
Creatinine / blood
Heart Failure / etiology*, genetics, physiopathology
Inflammation / blood, genetics
Kidney Failure, Chronic / blood, complications, therapy*
Leukocytes, Mononuclear / metabolism
RNA, Messenger / genetics*
Receptor, Adenosine A2A / blood, genetics*
Reverse Transcriptase Polymerase Chain Reaction
Severity of Illness Index
Stroke Volume / physiology
Ventricular Dysfunction, Left / complications*, genetics, physiopathology
|0/Biological Markers; 0/RNA, Messenger; 0/Receptor, Adenosine A2A; 58-61-7/Adenosine; 60-27-5/Creatinine|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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