Document Detail


Influence of haemodialysis and left ventricular failure on peripheral A(2A) adenosine receptor expression.
MedLine Citation:
PMID:  17132707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Haemodialysis (HD) sometimes accelerates left ventricular failure (LVF). As adenosine (ADO) is strongly implicated in cardiovascular functions, particularly via A(2A) receptor activation and as changes of peripheral A(2A) receptors mirror changes occurring in the cardiovascular system, we examined the influence of HD and LVF on both ADO plasma concentration and the expression of A(2A) receptors (i.e. Bmax, K(D) and mRNA amount) of peripheral blood mononuclear cells. METHODS: This cross-sectional study included 61 chronic renal failure (CRF) patients: 41 without LVF (24 haemodialysed and 17 undialysed) and 20 with LVF (9 haemodialysed and 11 undialysed). Ten LVF patients without CRF and 10 healthy subjects were also examined. RESULTS: (i) Bmax values of CRF patients without LVF were significantly decreased in undialysed patients compared with haemodialysed patients, and compared with controls (69 +/- 25 vs 98 +/- 33 vs 180 +/- 60 fmol/mg of protein, P < 0.05). Bmax values of CRF patients with LVF were lower in undialysed patients than in haemodialysed patients (60 +/- 27 vs 101 +/- 27 fmol/mg of protein, P < 0.05). Bmax values of LVF patients without CRF were lower than in controls (51 +/- 19 vs 180 +/- 60 fmol/mg of protein). (ii) A(2A) mRNA expression was increased in haemodialysed patients compared with controls (20.2 +/- 0.75 vs 17.6 +/- 1.3, P < 0.05). (iii) ADO plasma levels were high in haemodialysed patients and further increased during the HD sessions. CONCLUSION: The number of A(2A) receptors was decreased by CRF with or without LVF. However, this decrease was less important in haemodialysed patients. The changes in peripheral A(2A) receptor expression suggest a significant inflammatory response to HD and heart or kidney failure. Whether these changes do reflect alterations in cardiomyocytes needs further investigation.
Authors:
Louis Carrega; Emmanuel Fenouillet; Philippe Giaime; Annie Charavil; Laurence Mercier; Victoria Gerolami; Jean-Louis Berge-Lefranc; Yvon Berland; Jean Ruf; Alain Saadjian; Bertrand Dussol; Regis Guieu
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Publication Detail:
Type:  Journal Article     Date:  2006-11-28
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  22     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-05-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  851-6     Citation Subset:  IM    
Affiliation:
FRE2738 CNRS/Université de la Méditerranée, Faculté de Médecine Nord, Bd P. Dramard, 13015 Marseille, France.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / blood
Adult
Aged
Aged, 80 and over
Biological Markers / blood
Blood Urea Nitrogen
Chromatography
Creatinine / blood
Cross-Sectional Studies
Female
Freeze Drying
Gene Expression*
Heart Failure / etiology*,  genetics,  physiopathology
Humans
Inflammation / blood,  genetics
Kidney Failure, Chronic / blood,  complications,  therapy*
Leukocytes, Mononuclear / metabolism
Male
Middle Aged
Prognosis
RNA, Messenger / genetics*
Receptor, Adenosine A2A / blood,  genetics*
Renal Dialysis*
Reverse Transcriptase Polymerase Chain Reaction
Severity of Illness Index
Stroke Volume / physiology
Ventricular Dysfunction, Left / complications*,  genetics,  physiopathology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/RNA, Messenger; 0/Receptor, Adenosine A2A; 58-61-7/Adenosine; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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