| Influence of the gut microflora and of biliary constituents on morphological changes in the small intestine in obstructive jaundice. | |
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MedLine Citation:
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PMID: 9187547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased amounts of intestinal endotoxin are absorbed in obstructive jaundice. The precise mechanism is not known but the increased absorption may arise from alterations in the luminal contents, in the intestinal flora, in the gut wall or in interactions between all three. To examine the effects of the intestinal flora we have compared the morphological changes in the small intestine in obstructive jaundice in germ free and conventional rats while the effects of bile constituents have been examined by addition of bile constituents to the diet of bile duct ligated rats. Changes in the intestine were examined, histologically, by enzyme histochemistry, and by transmission and scanning electron microscopy. The results showed no differences in response between germ free and conventional rats. Feeding of diets containing bile salts exacerbated the lesion. Feeding of diets containing cholesterol, however, reduced the degree of intestinal changes produced by cholestasis and completely antagonised the increase in damage caused by feeding of bile salts. |
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Authors:
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M S Quraishy; D Chescoe; J Mullervy; M Coates; R H Hinton; M E Bailey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: HPB surgery : a world journal of hepatic, pancreatic and biliary surgery Volume: 10 ISSN: 0894-8569 ISO Abbreviation: HPB Surg Publication Date: 1996 |
Date Detail:
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Created Date: 1997-07-28 Completed Date: 1997-07-28 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 9002972 Medline TA: HPB Surg Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 11-20 Citation Subset: IM |
Affiliation:
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Department of Surgery, Royal Surrey County Hospital, Guildford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / chemistry* Bile Acids and Salts / pharmacology Cholestasis / complications, pathology* Endotoxemia / complications, pathology* Germ-Free Life Jejunum / microbiology*, ultrastructure Male Microscopy, Electron, Scanning Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): HPB Surg ISSN: 0894-8569 ISSN: 1607-8462 Publisher: Hindawi Publishing Corporation |
Article Information Download PDF  Copyright ? 1996 Hindawi Publishing Corporation. open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received Day: 19 Month: 8 Year: 1993 Print publication date: Year: 1996 Volume: 10 Issue: 1 First Page: 11 Last Page: 20 ID: 2423832 PubMed Id: 9187547 Publisher Item Identifier: S0894856996431599 DOI: 10.1155/1996/43159 |
| Influence of the Gut Microflora and of Biliary Constituents on Morphological Changes in the Small Intestine in Obstructive Jaundice | |
| M. Saeed Quraishy1 | |
| Dawn Chescoe1 | |
| Jenny Mullervy1 | |
| Marie Coates2 | |
| Richard H. Hinton2 | |
| Michael E. Bailey3 | |
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1Microstructural Studies UnitUniversity of SurreyGuildfordSurreyGU2 5XHUK |
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2School of Biological ScienceUniversity of SurreyGuildfordSurreyGU2 5XHUK |
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3Department of SurgeryRoyal Surrey County HospitalGuildfordSurreyGU2 5XXUK |
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