Document Detail

Influence of the gut microflora and of biliary constituents on morphological changes in the small intestine in obstructive jaundice.
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MedLine Citation:
PMID:  9187547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased amounts of intestinal endotoxin are absorbed in obstructive jaundice. The precise mechanism is not known but the increased absorption may arise from alterations in the luminal contents, in the intestinal flora, in the gut wall or in interactions between all three. To examine the effects of the intestinal flora we have compared the morphological changes in the small intestine in obstructive jaundice in germ free and conventional rats while the effects of bile constituents have been examined by addition of bile constituents to the diet of bile duct ligated rats. Changes in the intestine were examined, histologically, by enzyme histochemistry, and by transmission and scanning electron microscopy. The results showed no differences in response between germ free and conventional rats. Feeding of diets containing bile salts exacerbated the lesion. Feeding of diets containing cholesterol, however, reduced the degree of intestinal changes produced by cholestasis and completely antagonised the increase in damage caused by feeding of bile salts.
Authors:
M S Quraishy; D Chescoe; J Mullervy; M Coates; R H Hinton; M E Bailey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  HPB surgery : a world journal of hepatic, pancreatic and biliary surgery     Volume:  10     ISSN:  0894-8569     ISO Abbreviation:  HPB Surg     Publication Date:  1996  
Date Detail:
Created Date:  1997-07-28     Completed Date:  1997-07-28     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  9002972     Medline TA:  HPB Surg     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  11-20     Citation Subset:  IM    
Affiliation:
Department of Surgery, Royal Surrey County Hospital, Guildford, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile / chemistry*
Bile Acids and Salts / pharmacology
Cholestasis / complications,  pathology*
Endotoxemia / complications,  pathology*
Germ-Free Life
Jejunum / microbiology*,  ultrastructure
Male
Microscopy, Electron, Scanning
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Bile Acids and Salts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): HPB Surg
ISSN: 0894-8569
ISSN: 1607-8462
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright ? 1996 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 19 Month: 8 Year: 1993
Print publication date: Year: 1996
Volume: 10 Issue: 1
First Page: 11 Last Page: 20
ID: 2423832
PubMed Id: 9187547
Publisher Item Identifier: S0894856996431599
DOI: 10.1155/1996/43159

Influence of the Gut Microflora and of Biliary Constituents on Morphological Changes in the Small Intestine in Obstructive Jaundice
M. Saeed Quraishy1
Dawn Chescoe1
Jenny Mullervy1
Marie Coates2
Richard H. Hinton2
Michael E. Bailey3
1Microstructural Studies UnitUniversity of SurreyGuildfordSurreyGU2 5XHUK
2School of Biological ScienceUniversity of SurreyGuildfordSurreyGU2 5XHUK
3Department of SurgeryRoyal Surrey County HospitalGuildfordSurreyGU2 5XXUK


Article Categories:
  • Research Article


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