Document Detail


Influence of glucose and other substrates on electric field and polyethylene glycol-mediated transformation of intact yeast cells.
MedLine Citation:
PMID:  7926665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prepulse incubation with 2% glucose (mannose, fructose) strongly inhibited electrotransformation of intact yeast cells. This inhibitory effect was not due to alterations of cell viability or to cell membrane electropermeabilization, and was not affected by the solution buffer properties of preincubation and pulsing media. The electrotransformation efficiency was not modified by non-metabolized substances, such as sorbitol or alose. The glucose inhibition of electrotransformation was fast, occurring after only a 3-5-min preincubation. The postpulse incubation with substrate also decreased transformation efficiency, but was pH-dependent. We observed a similar, strong inhibitory effect of glucose when cells were transformed chemically. A pH dependence of yeast electrotransformation was established.
Authors:
V Ganeva; B Galutzov; J Teissie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEMS microbiology letters     Volume:  121     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-11-09     Completed Date:  1994-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
Affiliation:
Department of Biophysics and Radiobiology, Faculty of Biology, Sofia University, Bulgaria.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / analysis
Electricity
Glucose / pharmacology*
Hydrogen-Ion Concentration
Polyethylene Glycols / pharmacology*
Saccharomyces cerevisiae / cytology*
Transformation, Genetic
Chemical
Reg. No./Substance:
0/Polyethylene Glycols; 50-99-7/Glucose; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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