| Influence of globin structure on the heme in dromedary carbonmonoxyhemoglobin. | |
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MedLine Citation:
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PMID: 2605205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By use of X-ray absorption near-edge structure (XANES), circular dichroism, and visible absorption spectroscopies, dromedary carbonmonoxyhemoglobin has been characterized structurally and functionally. By consideration of the experimental results the following view emerges: (i) the quaternary structure is not the unique factor determining the tertiary environment around the heme, and (ii) the multiplicity of interactions between hemoglobin and solvent components induces a large number of globin conformations, which somehow affect the conformation of the heme such that the structural parameters (i.e., the doming of porphyrins, the movements of the iron relative to the heme plane, the distortion of the ligand field, and the change in the Fe-C-O angle) can be uncoupled. |
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Authors:
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G Amiconi; R Santucci; M Coletta; A C Castellano; A Giovannelli; M Dell'Ariccia; S Della Longa; M Barteri; E Burattini; A Bianconi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemistry Volume: 28 ISSN: 0006-2960 ISO Abbreviation: Biochemistry Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1990-02-15 Completed Date: 1990-02-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370623 Medline TA: Biochemistry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 8547-53 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Biochimiche, Universitá degli Studi La Sapienza, Roma, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Camels Carboxyhemoglobin* Chemistry, Physical Circular Dichroism Globins* Heme* Kinetics Molecular Conformation Molecular Structure Physicochemical Phenomena Protein Conformation Spectrum Analysis |
| Chemical | |
Reg. No./Substance:
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14875-96-8/Heme; 9004-22-2/Globins; 9061-29-4/Carboxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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