| Influence of ghrelin on the gastric accommodation reflex and on meal-induced satiety in man. | |
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MedLine Citation:
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PMID: 19210631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ghrelin increases gastric tone in the fasting state and enhances gastric emptying in gastroparesis. The aims of the study were to evaluate the effect of ghrelin on postprandial gastric tone and on meal-induced satiety in health. Ten healthy volunteers underwent a barostat study on two occasions. After determination of intra-abdominal pressure (minimal distending pressure, MDP), isobaric volume measurement was performed for 90 min at MDP + 2 mmHg. After 20 min, ghrelin (40 microg) or saline was administered i.v. over 30 min in a double-blind-randomized cross-over design, followed 10 min later by a liquid meal (200 mL, 300 kcal). Stepwise isobaric distentions (+2 mmHg per 2 min) were performed 60 min after the meal. Data (mean +/- SEM) were compared using paired Student's t-test and ANOVA. Separately, a satiety drinking test (15 mL min(-1) until satiety score 5) was performed on 10 subjects twice, after treatment with placebo or ghrelin. Ghrelin infusion significantly inhibited gastric accommodation (mean volume increase adjusted means 108.0 +/- 50 vs 23.0 +/- 49 mL, P = 0.03, ANCOVA with the premeal postinfusion volume as covariate) and reduced postprandial gastric volumes (197.2 +/- 24.6 vs 353.5 +/- 50.0 mL, P = 0.01). Pressures inducing perception or discomfort during postprandial gastric distentions were not altered. During satiety testing, ghrelin did not alter nutrient volume ingested till maximal satiety (637.5 +/- 70.9 vs 637.5 +/- 56.2 mL, ns). Ghrelin administered during the meal significantly inhibits gastric accommodation in health, but this is not associated with early satiation. |
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Authors:
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D Ang; H Nicolai; R Vos; K Mimidis; F Akyuz; S Kindt; P Vanden Berghe; D Sifrim; I Depoortere; T Peeters; J Tack |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2008-01-30 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 21 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-12 Completed Date: 2009-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 528-33, e8-9 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Department of Pathophysiology, University of Leuven, Leuven, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Over Studies Double-Blind Method Eating Female Gastric Emptying / drug effects*, physiology Ghrelin / pharmacology* Humans Male Muscle Contraction / drug effects, physiology Postprandial Period / drug effects Pressure Random Allocation Reflex / drug effects*, physiology Satiety Response / drug effects*, physiology Sensation / drug effects Stomach* / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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