| Influence of germ cells upon transferrin secretion by rat Sertoli cells in vitro. | |
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MedLine Citation:
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PMID: 3183569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Indirect approach (hypotonic treatment) and direct approaches (co-cultures and conditioned media) were used in order to investigate the effects of germ cells from adult rats upon transferrin secretion by Sertoli cell cultures prepared from 20-day-old rats. Removal of germ cells contaminating the Sertoli cell cultures resulted in a significant decrease in transferrin secretion whereas the addition of crude germ cell preparations or of enriched preparations of pachytene spermatocytes, early spermatids and of liver epithelial cells (LEC) markedly stimulated this parameter. Furthermore, spent media of pachytene spermatocytes and of early spermatids, but not of LEC, also stimulated transferrin production. It is concluded that germ cells normally located within the adluminal compartment of the seminiferous tubules may be capable of controlling their own supply of iron via their influence upon transferrin secretion by the Sertoli cells. |
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Authors:
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B Le Magueresse; C Pineau; F Guillou; B Jégou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of endocrinology Volume: 118 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-12-22 Completed Date: 1988-12-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: R13-6 Citation Subset: IM |
Affiliation:
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Université de Rennes I, UA CNRS 256, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Epithelium / physiology Liver / physiology* Male Rats Rats, Inbred Strains Sertoli Cells / metabolism* Spermatozoa / physiology* Transferrin / metabolism* |
| Chemical | |
Reg. No./Substance:
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11096-37-0/Transferrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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