Document Detail

Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: a MRI study.
MedLine Citation:
PMID:  12799748     Owner:  NLM     Status:  MEDLINE    
Cerebrospinal fluid (CSF) space enlargement in schizophrenia is a prominent finding. This study was initiated to examine the influence of genetic loading, obstetric complications and premorbid adjustment on the extent of this enlargement. The sample of this MRI study consisted of 40 schizophrenic patients, 24 psychiatric and 40 healthy family members from 10 uniaffected and 19 multiple affected families with schizophrenia, such as 27 control subjects from non-affected families. The ventricle-to-brain-ratio (VBR), and the areas of the third ventricle, sylvian fissure, temporal horn and interhemispheric fissure at the slice where these structures reached their maximum were examined relatively to the corresponding total brain areas. The sum of CSF areas was calculated as a parameter for global atrophy. From MANCOVA adjusted for intervening variables the right VBR and the sum of CSF areas revealed significant differences between diagnostic groups. For these areas schizophrenic patients showed an increase compared to control subjects and family members with psychiatric disorder. Genetic loading influenced the interhemispheric fissure, enlarged in multiple affected compared to uniaffected families, and the temporal horn asymmetry, which was right sided (right > left) in control subjects and multiple affected families, but inverted in uniaffected families. Neonatal obstetric complications influenced only the size of the VBR, while premorbid adjustment predicted various CSF areas. In conclusion, schizophrenic subjects from multiple and uniaffected families showed a global atrophy, which was most pronounced in the VBR. Genetic loading seems to have an impact on frontal regions as the interhemispheric fissure and on the temporal horn.
Peter Falkai; Thomas Schneider-Axmann; William G Honer; Kai Vogeley; Helmut Schönell; Ute Pfeiffer; Harald Scherk; Wolfgang Block; Frank Träber; Hans H Schild; Wolfgang Maier; Ralf Tepest
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European archives of psychiatry and clinical neuroscience     Volume:  253     ISSN:  0940-1334     ISO Abbreviation:  Eur Arch Psychiatry Clin Neurosci     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-06-11     Completed Date:  2003-09-22     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9103030     Medline TA:  Eur Arch Psychiatry Clin Neurosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  92-9     Citation Subset:  IM    
Department of Psychiatry and Psychotherapy, University of the Saarland, 66421 Homburg/Saar, Germany.
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MeSH Terms
Brain / pathology*
Case-Control Studies
Cerebral Ventricles / pathology
Genetic Predisposition to Disease
Magnetic Resonance Imaging
Middle Aged
Obstetric Labor Complications*
Schizophrenia / etiology*,  genetics,  pathology*

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