| Influence of genetic factors in the modulation of postprandial lipemia. | |
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MedLine Citation:
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PMID: 18603482 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postprandial lipemia is traditionally defined by the extent and duration of the increase in plasma triglycerides in response to a fat-enriched meal. The relationship between alimentary lipemia and coronary disease is of great interest in view of the epidemiological and experimental evidence that underlies it. The rate of synthesis of triglyceride-rich lipoproteins, lipoprotein lipase-mediated triglyceride hydrolysis, and the hepatic capture of chylomicron remnants via the interaction of the lipoprotein receptor with APOE and LPL, are the fundamental pillars of the metabolism and modification of these lipoproteins. The modulation of such phenomena is influenced by both genetic and environmental factors, thus explaining their extraordinary individual variance. This review presents the current evidence linking a number of candidate genes to the modulation of postprandial lipid metabolism. |
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Authors:
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Pablo Perez-Martinez; Jose Lopez-Miranda; Francisco Perez-Jimenez; Jose M Ordovas |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2008-07-07 |
Journal Detail:
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Title: Atherosclerosis. Supplements Volume: 9 ISSN: 1567-5688 ISO Abbreviation: Atheroscler Suppl Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-08 Completed Date: 2009-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100973461 Medline TA: Atheroscler Suppl Country: Netherlands |
Other Details:
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Languages: eng Pagination: 49-55 Citation Subset: IM |
Affiliation:
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Nutrition and Genomics Laboratory, J.M.-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoproteins / genetics*, metabolism Chylomicrons / genetics*, metabolism Dyslipidemias / genetics*, metabolism Genetic Predisposition to Disease Humans Polymorphism, Genetic* Postprandial Period / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL54776/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 0/Chylomicrons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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