Document Detail


Influence of furosemide on hemodynamic responses during exercise in horses.
MedLine Citation:
PMID:  1524299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four hours prior to exercise on a high-speed treadmill, 4 dosages of furosemide (0.25, 0.50, 1.0, and 2.0 mg/kg of body weight) and a control treatment (10 ml of 0.9% NaCl) were administered IV to 6 horses. Carotid arterial pressure (CAP), pulmonary arterial pressure (PAP), and heart rate were not different in resting horses before and 4 hours after furosemide administration. Furosemide at dosage of 2 mg/kg reduced resting right atrial pressure (RAP) 4 hours after furosemide injection. During exercise, increases in treadmill speed were associated with increases in RAP, CAP, PAP, and heart rate. Furosemide (0.25 to 2 mg/kg), administered 4 hours before exercise, reduced RAP and PAP during exercise in dose-dependent manner, but did not influence heart rate. Mean CAP was reduced by the 2-mg/kg furosemide dosage during exercise at 9 and 11 m/s, but not at 13 m/s. During recovery, only RAP was decreased by furosemide administration. Plasma lactate concentration was not significantly influenced by furosemide administration. Furosemide did not influence PCV or hemoglobin concentration at rest prior to exercise, but did increase both variables in dose-dependent manner during exercise and recovery. However, the magnitude of the changes in PCV and hemoglobin concentration were small in comparison with changes in RAP and PAP, and indicate that furosemide has other properties in addition to its diuretic activities. Furosemide may mediate some of its cardiopulmonary effects by vasodilatory activities that directly lower pulmonary arterial pressure, but also increase venous capacitance, thereby reducing venous return to the atria and cardiac filling.
Authors:
S C Olsen; C P Coyne; B S Lowe; N Pelletier; E M Raub; H H Erickson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of veterinary research     Volume:  53     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-10-15     Completed Date:  1992-10-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  742-7     Citation Subset:  IM    
Affiliation:
Departments of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Body Weight / drug effects
Dose-Response Relationship, Drug
Exercise Test
Furosemide / pharmacology*
Heart Rate / drug effects
Hematocrit / veterinary
Hemodynamics / drug effects*
Hemoglobins / analysis
Horses / blood,  physiology*
Lactates / blood
Male
Physical Exertion / drug effects*
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Lactates; 54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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