| Influence of furosemide on hemodynamic responses during exercise in horses. | |
MedLine Citation:
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PMID: 1524299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four hours prior to exercise on a high-speed treadmill, 4 dosages of furosemide (0.25, 0.50, 1.0, and 2.0 mg/kg of body weight) and a control treatment (10 ml of 0.9% NaCl) were administered IV to 6 horses. Carotid arterial pressure (CAP), pulmonary arterial pressure (PAP), and heart rate were not different in resting horses before and 4 hours after furosemide administration. Furosemide at dosage of 2 mg/kg reduced resting right atrial pressure (RAP) 4 hours after furosemide injection. During exercise, increases in treadmill speed were associated with increases in RAP, CAP, PAP, and heart rate. Furosemide (0.25 to 2 mg/kg), administered 4 hours before exercise, reduced RAP and PAP during exercise in dose-dependent manner, but did not influence heart rate. Mean CAP was reduced by the 2-mg/kg furosemide dosage during exercise at 9 and 11 m/s, but not at 13 m/s. During recovery, only RAP was decreased by furosemide administration. Plasma lactate concentration was not significantly influenced by furosemide administration. Furosemide did not influence PCV or hemoglobin concentration at rest prior to exercise, but did increase both variables in dose-dependent manner during exercise and recovery. However, the magnitude of the changes in PCV and hemoglobin concentration were small in comparison with changes in RAP and PAP, and indicate that furosemide has other properties in addition to its diuretic activities. Furosemide may mediate some of its cardiopulmonary effects by vasodilatory activities that directly lower pulmonary arterial pressure, but also increase venous capacitance, thereby reducing venous return to the atria and cardiac filling. |
Authors:
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S C Olsen; C P Coyne; B S Lowe; N Pelletier; E M Raub; H H Erickson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: American journal of veterinary research Volume: 53 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-10-15 Completed Date: 1992-10-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 742-7 Citation Subset: IM |
Affiliation:
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Departments of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Body Weight / drug effects Dose-Response Relationship, Drug Exercise Test Furosemide / pharmacology* Heart Rate / drug effects Hematocrit / veterinary Hemodynamics / drug effects* Hemoglobins / analysis Horses / blood, physiology* Lactates / blood Male Physical Exertion / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Lactates; 54-31-9/Furosemide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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