Document Detail

Influence of free testosterone on antigen levels of plasminogen activator inhibitor-1 in premenopausal women with central obesity.
MedLine Citation:
PMID:  1736034     Owner:  NLM     Status:  MEDLINE    
Women with upper body obesity are at increased risk for cardiovascular disease (CVD). Several studies have demonstrated a reduced fibrinolytic activity in these patients, mainly due to an enhanced activity of plasminogen activator inhibitor-1 (PAI-1). Since an increase of androgenic activity is a feature of central obesity in women, the present study was aimed at evaluating the possibility of a relationship between androgens and PAI-1 (antigen and activity) in 20 premenopausal women, 10 with upper body obesity and 10 controls. In obese women, PAI-1 antigen showed a positive Pearson correlation with free testosterone (FT), insulin, c-peptide, triglycerides (TG), and waist to hip ratio (WHR) (P less than .01), whereas PAI-1 activity correlated positively only with insulin and WHR (P less than .01). In control women, PAI-1 antigen and activity were positively related only to TG (P less than .01). When we applied the multiple regression model with stepwise backward method to our data, both PAI-1 antigen and activity did not maintain any significant association. However, when the data from both the groups were pooled (n = 20), and PAI-1 antigen was considered as the dependent variable, body weight (Sig T = 0.0001), TG (Sig T = 0.0053), FT (Sig T = 0.013), and luteinizing hormone (LH) (Sig T = 0.0474) met the stepwise criteria, suggesting an independent effect of each of these parameters on PAI-1 antigen. On the other hand, when PAI-1 activity was tested as the dependent variable, only body weight maintained a significant relationship with this parameter (Sig T = 0.0006).(ABSTRACT TRUNCATED AT 250 WORDS)
G De Pergola; V De Mitrio; A Perricci; M Cignarelli; G Garruti; S Lomuscio; G Ferri; O Schiraldi; R Giorgino
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  41     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-06     Completed Date:  1992-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  131-4     Citation Subset:  IM    
Istituto di Clinica Medica, Endocrinologia e Malattie del Ricambio, Università di Bari, Italy.
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MeSH Terms
C-Peptide / blood*
Follicle Stimulating Hormone / blood*
Insulin / blood*
Luteinizing Hormone / blood*
Middle Aged
Obesity / blood*
Plasminogen Inactivators / blood*,  metabolism
Reference Values
Sex Hormone-Binding Globulin / analysis
Testosterone / blood*
Reg. No./Substance:
0/C-Peptide; 0/Plasminogen Inactivators; 0/Sex Hormone-Binding Globulin; 11061-68-0/Insulin; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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