Document Detail

Influence of foot orientation on the appearance and quantification of 1H magnetic resonance muscle spectra obtained from the soleus and the vastus lateralis.
MedLine Citation:
PMID:  22298295     Owner:  NLM     Status:  MEDLINE    
Muscle (1)H magnetic resonance spectroscopy noninvasively measures intramyocellular lipid levels, which correlate with obesity, insulin resistance, and type 2 diabetes. The appearance of muscle magnetic resonance spectra is influenced by bulk magnetic susceptibility and residual dipolar couplings which depend on the angle between the muscle fibers and the main magnetic field. This study used a 4 T magnet to examine the influence of foot orientation on the appearance and quantification of muscle magnetic resonance spectra from the soleus and the vastus lateralis. For each individual, intramyocellular lipid, extramyocellular lipid, and creatine concentrations were quantified in the soleus and the vastus lateralis during one session. Foot orientation was found to influence the appearance of muscle spectra from the soleus but not from the vastus lateralis. It was concluded that quantifying intramyocellular lipid by the standard LCModel using a water reference may be more appropriate than using a creatine reference in the presence of residual dipolar couplings.
Małgorzata Marjańska; Lynn E Eberly; Gregor Adriany; Sarah N Verdoliva; Michael Garwood; Lisa Chow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-02-01
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  68     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-22     Completed Date:  2013-05-29     Revised Date:  2014-03-27    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1731-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Biological Markers / analysis
Foot / physiology*
Lipids / analysis*
Magnetic Resonance Spectroscopy / methods*
Muscle, Skeletal / metabolism*
Patient Positioning / methods*
Protons / diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Grant Support
5K12RR023247-02/RR/NCRR NIH HHS; K12 RR023247-02/RR/NCRR NIH HHS; P41 RR008079/RR/NCRR NIH HHS; P41 RR008079/RR/NCRR NIH HHS; P41 RR008079-13/RR/NCRR NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Lipids; 0/Protons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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