Document Detail


Influence of food on tianeptine and its main metabolite kinetics.
MedLine Citation:
PMID:  3243929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of a test meal on the absorption and disposition of tianeptine (Stablon), a new antidepressant, was investigated in 12 healthy subjects in a two-way, randomized, open cross-over study. Single 12.5-mg oral doses of tianeptine were administered following a night of fasting or immediately after a standardized breakfast. When subjects received tianeptine under fasting conditions the lag time before absorption onset, and the time of the maximum plasma concentration were 0.55 +/- 0.26 hours and 1.29 +/- 0.29 hours, respectively. The maximum plasma concentration was 322 +/- 44 ng/mL, and the total area under the curve 994 +/- 248 ng/hr/mL. When tianeptine was given at the end of the meal, several significant changes were found for tianeptine kinetic parameters; the lag time increased by 0.3 hour and the maximum plasma concentration was lowered (decreased by 25%) and occurred later (tmax increased by 0.5 hour). However, no significant change was found in the area under the plasma concentration-time curve. The trend and extent of changes in the MC5 metabolite parameters were similar to those observed for the parent drug. Absorption of tianeptine is slightly delayed and slowed down without modification of its extent when tianeptine is given at the end of a meal. These slight changes are not clinically relevant for an antidepressant administered three times a day. Despite the changes observed, tianeptine may be given at meal times to improve compliance with treatment.
Authors:
A Dresse; J M Rosen; H Brems; H Masset; R Defrance; C Salvadori
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  28     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1115-9     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie, Université de Liège, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antidepressive Agents, Tricyclic / metabolism,  pharmacokinetics*
Food*
Humans
Male
Random Allocation
Thiazepines / metabolism,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 0/Thiazepines; 66981-73-5/tianeptine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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