Document Detail

Influence of food and diabetes on pharmacokinetics of sodium tungstate in rat.
MedLine Citation:
PMID:  12429467     Owner:  NLM     Status:  MEDLINE    
In this paper, the influence of food and diabetes on the pharmacokinetics of sodium tungstate in rat was investigated. The compound was administered intravenously (9 mg/kg) and orally in the form of solution (36 mg/kg). An empirical Bayes methodology was used to compute individual pharmacokinetic parameters. Sodium tungstate followed first-order kinetics, and plasma concentration versus time data were described by a two-compartment model. A significant relationship was found between the bioavailability and the status of the animals. Total plasma clearance and elimination half-life averaged 3.1 ml/min/kg and 1.6 h, respectively. Food had some effects on the extent of sodium tungstate absorption. After oral administration, the bioavailability (0.67 versus 0.85), C(max) (6.10 versus 15.2 microg/ml) and AUC (70.7 versus 105 mgh/l) were 20, 60 and 32% lower in fed than in fasted rats, respectively. The presence of cellulose and sulphate anions in rat chow could partially explain the fed state-associated reduction of tungstate bioavailability. In streptozotocin-induced diabetic fed rats, a 25% decrease occurred in AUC and F, and a 14% increase occurred in the elimination rate constant compared with healthy fed rats. These changes could be explain on the one hand, by the increase of liquid consumption and food intake, and on the other hand, by a gastroparesis in the early diabetic rats.
S Le Lamer-Déchamps; P Poucheret; G Cros; F Bressolle
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  248     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-13     Completed Date:  2003-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  131-9     Citation Subset:  IM    
Clinical Pharmacokinetic Laboratory, Faculty of Pharmacy, 34093 Montpellier Cedex 5, France.
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MeSH Terms
Area Under Curve
Biological Availability
Diabetes Mellitus, Experimental / blood,  metabolism*
Eating / physiology
Food-Drug Interactions / physiology*
Rats, Sprague-Dawley
Tungsten Compounds / administration & dosage,  blood,  pharmacokinetics*
Reg. No./Substance:
0/Tungsten Compounds; 13472-45-2/sodium tungstate(VI)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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