Document Detail


Influence of food on absorption of erythromycin ethyl succinate.
MedLine Citation:
PMID:  6969579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythromycin plasma concentrations were determined in 18 subjects after a single dose (800 mg) of a new formulation of erythromycin ethyl succinate taken immediately before, immediately after, and 1 h after food. Adequate absorption occurred with all treatments, although bioavailability was best when the drug was taken before food. Absorption was delayed by food, with the highest and earliest peak plasma erythromycin levels occurring under fasting conditions.
Authors:
P J Thompson; K R Burgess; G E Marlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  18     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  829-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Erythromycin / analogs & derivatives*,  metabolism
Erythromycin Ethylsuccinate
Food*
Humans
Intestinal Absorption*
Kinetics
Male
Chemical
Reg. No./Substance:
114-07-8/Erythromycin; 1264-62-6/Erythromycin Ethylsuccinate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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