Document Detail

Influence of folic acid-fortified foods on folate status in a folate depletion-repletion rat model.
MedLine Citation:
PMID:  11348558     Owner:  NLM     Status:  MEDLINE    
An increasing number of foods fortified with varying levels of folic acid are appearing in the market place, targeted either at the general population or at specific consumer groups. Although it is assumed that the folate in these products should be highly bioavailable, there is a need to carry out studies to ascertain that this is, in fact, the case. The present study investigated the ability of selected folic acid-fortified foods (targeted at different types of consumer) to increase the folate status of folate-deficient rats. Forty-two weanling male rats (Wistar strain) were fed a folate-deficient diet containing 1 % succinyl sulfathiazole (w/w) for 28 d. Following depletion, seven rats were randomly assigned to each of five repletion diets containing folic acid, Complan, Slim Fast, Opti-Fuel2 or Cola Coa calculated to provide 200 microg folate/kg of each diet. Calculations were based on folate information from the product labels. After a further 28 d, plasma, liver and kidney folate concentrations were determined by microbiological assay. Plasma homocysteine was measured by HPLC as a functional indicator of folate status. The folate content of the foods was measured by tri-enzyme extraction followed by microbiological assay. Our analyses suggest that there may be considerable inaccuracies on the part of the manufacturers in relation to the folate declarations on the product labels. Despite this, the four foods evaluated were highly effective in elevating plasma, liver and kidney folate and lowering plasma homocysteine concentrations in rats. These results lend support to the policy of food fortification with folic acid as a means of raising the folate status of the population, and in particular to the fortification of specific foods which may target areas of the population where increased folate status is most needed.
K O'Leary; P J Sheehy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  85     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-11     Completed Date:  2001-05-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  IM    
Nutritional Sciences, Department of Food Science and Technology, University College, Cork, Republic of Ireland.
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MeSH Terms
3T3 Cells / drug effects
Folic Acid / blood,  pharmacokinetics*
Folic Acid Deficiency / blood,  metabolism*
Food, Fortified*
Homocysteine / blood
Kidney / metabolism
Liver / metabolism
Rats, Wistar
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid

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