Document Detail

Influence of fibrin, fibrinogen and fibrinogen degradation products on cultured endothelial cells.
MedLine Citation:
PMID:  6882509     Owner:  NLM     Status:  MEDLINE    
Thin films of a fibrin-agar mixture induced significant morphological changes in porcine aortic endothelial cells in vitro. The cells became spindle shaped, piled up and consequently the intercellular spaces widened. These morphological changes became more significant with higher concentrations of fibrin. Films of fibrinogen-agar or thrombin-agar mixtures induced no such morphological changes thereby suggesting that fibrin itself injures the endothelial cells. Despite the lack of morphological effects of fibrinogen degradation product D or E on cultured endothelial cells, lower molecular weight fibrinogen degradation products separated by Sephadex G-25 chromatography did induce injury in the endothelial cells. As damage to the endothelium is a key event in initiation of atherosclerosis, fibrinogen and its metabolites probably play important roles.
K Watanabe; K Tanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  48     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  57-70     Citation Subset:  IM    
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MeSH Terms
Aorta / cytology,  drug effects*
Cell Differentiation / drug effects*
Culture Techniques
Endothelium / cytology,  drug effects
Fibrin / pharmacology*
Fibrin Fibrinogen Degradation Products / pharmacology*
Fibrinogen / pharmacology*
Thrombin / pharmacology
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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