| Influence of fever on cefazolin pharmacokinetics. | |
MedLine Citation:
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PMID: 10078779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of fever on the pharmacokinetics of cefazolin was investigated in patients with acute febrile diseases. Nine patients were included in the study. Antibiotic serum concentrations were determined using high performance liquid chromatograpy (HPLC). An analog computer and the SIMULINK software package were used to identify the pharmacokinetic model and PCNONLIN software package to obtain the secondary parameters. In 6 patients a two-compartment pharmacokinetic model of cefazolin was observed during fever and after defervescence. In 2 patients a two-compartment model changed to a one-compartment after defervescence, and a one-compartment model was observed in one patient during both periods. Cefazolin-treated patients with a two-compartment model (6/9) had higher Cmax, mean steady state serum concentrations (Css), and area under the plasma concentration-time curve (AUC(0-->infinity)), smaller central compartment volume (V1), and lower clearance (Cl) during fever. The varying distribution of antibiotics during fever probably reflects different hemodynamic responses to fever. |
Authors:
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B Beović; A Mrhar; R Karba; T Zupancic; I Grabnar; A Belic; M Marolt-Gomiscek |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of chemotherapy (Florence, Italy) Volume: 11 ISSN: 1120-009X ISO Abbreviation: J Chemother Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-05-27 Completed Date: 1999-05-27 Revised Date: 2009-08-04 |
Medline Journal Info:
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Nlm Unique ID: 8907348 Medline TA: J Chemother Country: ITALY |
Other Details:
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Languages: eng Pagination: 40-5 Citation Subset: IM |
Affiliation:
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Department of Infectious Diseases, University Medical Center Ljubljana, Slovenia. Bojana.Beovic@mf.uni-lj.si |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Area Under Curve Cefazolin / blood, pharmacokinetics* Cephalosporins / blood, pharmacokinetics* Chromatography, High Pressure Liquid Computer Simulation Female Fever / metabolism* Humans Male Middle Aged Models, Chemical Prospective Studies Software |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins; 25953-19-9/Cefazolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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