Document Detail

Influence of fever on cefazolin pharmacokinetics.
MedLine Citation:
PMID:  10078779     Owner:  NLM     Status:  MEDLINE    
The influence of fever on the pharmacokinetics of cefazolin was investigated in patients with acute febrile diseases. Nine patients were included in the study. Antibiotic serum concentrations were determined using high performance liquid chromatograpy (HPLC). An analog computer and the SIMULINK software package were used to identify the pharmacokinetic model and PCNONLIN software package to obtain the secondary parameters. In 6 patients a two-compartment pharmacokinetic model of cefazolin was observed during fever and after defervescence. In 2 patients a two-compartment model changed to a one-compartment after defervescence, and a one-compartment model was observed in one patient during both periods. Cefazolin-treated patients with a two-compartment model (6/9) had higher Cmax, mean steady state serum concentrations (Css), and area under the plasma concentration-time curve (AUC(0-->infinity)), smaller central compartment volume (V1), and lower clearance (Cl) during fever. The varying distribution of antibiotics during fever probably reflects different hemodynamic responses to fever.
B Beović; A Mrhar; R Karba; T Zupancic; I Grabnar; A Belic; M Marolt-Gomiscek
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  11     ISSN:  1120-009X     ISO Abbreviation:  J Chemother     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-05-27     Completed Date:  1999-05-27     Revised Date:  2009-08-04    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  40-5     Citation Subset:  IM    
Department of Infectious Diseases, University Medical Center Ljubljana, Slovenia.
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MeSH Terms
Area Under Curve
Cefazolin / blood,  pharmacokinetics*
Cephalosporins / blood,  pharmacokinetics*
Chromatography, High Pressure Liquid
Computer Simulation
Fever / metabolism*
Middle Aged
Models, Chemical
Prospective Studies
Reg. No./Substance:
0/Cephalosporins; 25953-19-9/Cefazolin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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