Document Detail


Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes.
MedLine Citation:
PMID:  22676722     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Please cite this paper as: Bustamante M, Danileviciute A, Espinosa A, Gonzalez JR, Subirana I, Cordier S, Chevrier C, Chatzi L, Grazuleviciene R, Sunyer J, Ibarluzea J, Ballester F, Villanueva CM, Nieuwenhuijsen M, Estivill X, Kogevinas M. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03400.x. A nested case-control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51-0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07-1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner.
Authors:
M Bustamante; A Danileviciute; A Espinosa; Jr Gonzalez; I Subirana; S Cordier; C Chevrier; L Chatzi; R Grazuleviciene; J Sunyer; J Ibarluzea; F Ballester; Cm Villanueva; M Nieuwenhuijsen; X Estivill; M Kogevinas
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-7
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  -     ISSN:  1471-0528     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.
Affiliation:
Centre for Research in Environmental Epidemiology, Barcelona, Spain Genetic Causes of Disease Group, Genes and Disease Programme, Centre for Genomic Regulation, Barcelona, Spain Vytautas Magnus University, Kaunas, Lithuania Hospital del Mar Research Institute, Barcelona, Spain Public Health and Epidemiology Network Biomedical Research Centre, Instituto de Salud Carlos III, Madrid, Spain Inserm, IRSET, Université Rennes, Rennes, France Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece Subdirección de Salud Pública-Gipuzkoa, San Sebastián, Spain Area de investigación en Ambiente y Salud, Centro Superior de Investigación en Salud Pública and Public Health and Epidemiology Network Biomedical Research Centre, Valencia, Spain University of Valencia, Valencia, Spain National School of Public Health, Athens, Greece.
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