Document Detail

Influence of feeding unsaturated fats on growth and immune status of mice.
MedLine Citation:
PMID:  8381477     Owner:  NLM     Status:  MEDLINE    
Dietary polyunsaturated fatty acids alter the lipid composition and immune systems of mice. To date, most studies have been of short duration and focused on a particular immunologic assay. Adult female mice were therefore fed diets rich in 18:1(n-9) (olive oil), 18:2(n-6) (safflower oil), 18:3(n-3) (linseed oil) or 20:5(n-3) and 22:6(n-3) (fish oil-safflower oil, 9:1, wt/wt), for a 5-mo period, encompassing two breeding cycles. Offspring from the second breeding cycle were then fed these diets for 42 d, and a spectrum of immune functions was assessed. Dietary fat had a small effect on gestational weight gain and total and relative organ weights of the offspring. The relative amounts of splenic Ly-2 and gamma delta receptor-expressing T cells were proportional to the concentration of 18:2(n-6), and inversely proportional to the concentration of long chain (n-3) polyenes in the diet. In contrast, Ly-1, immunoglobulin M, GM1+, and Ly-1 B suppressor inducer cells were not significantly affected by dietary fat. Splenic natural killer cell and lymphokine activated killer cell activities were attenuated by (n-3) polyunsaturated fatty acids, in contrast to superoxide production of stimulated macrophages which was increased. Those immune functions that were sensitive to dietary fat modulation will be the focus of continued research.
A Berger; J B German; B L Chiang; A A Ansari; C L Keen; M P Fletcher; M E Gershwin
Related Documents :
17120927 - Different kinetic in incorporation and depletion of n-3 fatty acids in erythrocytes and...
25028817 - Studies in fat grafting: part ii. effects of injection mechanics on material properties...
19953197 - Determinants of blood cell omega-3 fatty acid content.
17876197 - Mediterranean diet and n-3 fatty acids in the prevention and treatment of cardiovascula...
9393557 - Mice overexpressing human lecithin: cholesterol acyltransferase are not protected again...
23031467 - Impact of chicory inclusion in a cereal-based diet on digestibility, organ size and fae...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  123     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-05     Completed Date:  1993-03-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  225-33     Citation Subset:  IM    
Department of Food Science and Technology, Emory University, Atlanta, GA 30322.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Dietary Fats, Unsaturated / pharmacology*
Fish Oils / pharmacology
Gestational Age
Immunity / drug effects*
Interleukin-2 / biosynthesis,  pharmacology
Killer Cells, Lymphokine-Activated / immunology
Killer Cells, Natural / immunology
Linseed Oil / pharmacology
Litter Size
Macrophages / immunology
Organ Size / drug effects
Safflower Oil / pharmacology
Superoxides / metabolism
T-Lymphocytes / immunology
Time Factors
Weight Gain / drug effects*
Grant Support
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fish Oils; 0/Interleukin-2; 11062-77-4/Superoxides; 8001-23-8/Safflower Oil; 8001-26-1/Linseed Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of hypoxia on the accumulation of technetium-99m-glucarate and technetium-99m-gluconate by Ch...
Next Document:  Metabolic characteristics of pig colonocytes after adaptation to a high fiber diet.