Document Detail

Influence of feeding paradigm in rats on temporal pattern of: I. Macronutrient intake and arterio-venous differences in plasma glucose, insulin and tryptophan.
MedLine Citation:
PMID:  2085869     Owner:  NLM     Status:  MEDLINE    
Relationships among feeding paradigm (single diet vs food selection) and arterio-venous differences (delta AV) of glucose, insulin and tryptophan were studied by measuring the temporal patterns of food intake and plasma parameters during 8 hr feeding cycles in rats. Adult male Sprague-Dawley rats were offered a single diet of fixed composition (20% casein) or a choice between two isocaloric diets (0% and 60% casein) for 2 weeks under 8-hr daily feeding conditions, food being offered during the dark cycle. Groups of animals were then killed at the beginning and at 2-hourly intervals throughout the feeding period. With both feeding paradigms, rats showed temporal patterns of energy, carbohydrate and protein intakes with a peak at the beginning and a trough at the end of the feeding period. However, in rats offered a dietary choice the intake of carbohydrate was significantly lower, and the intakes of energy and protein significantly higher than those found in rats offered a single diet. Throughout the feeding period, these differences between single and choice diets became less accentuated in the case of carbohydrate intake, but more accentuated for energy and protein intakes. Paradoxically, rats fed a choice of diets had a significantly lower weight gain than rats fed a single diet. The temporal variation of insulin secretion and tryptophan absorption varied inversely with the two diet paradigms. Moreover, in rats offered a choice of diets, macronutrient intake was significantly correlated with insulin secretion and venous glucose concentration. The opposed physiologic and metabolic responses to the feeding paradigms suggest the need for future studies to examine the possibility that such can function as synchronizers of biological rhythms.
L Thibault
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chronobiology international     Volume:  7     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-23     Completed Date:  1991-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  283-9     Citation Subset:  IM    
School of Dietetics and Human Nutrition, Macdonald College of McGill University, Quebec, Canada.
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MeSH Terms
Blood Glucose / metabolism
Circadian Rhythm / physiology*
Feeding Behavior / physiology*
Insulin / blood
Rats, Inbred Strains
Tryptophan / blood
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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