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Influence of fatty acid on lipase-catalyzed synthesis of ascorbyl esters and their free radical scavenging capacity.
MedLine Citation:
PMID:  25224149     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fatty acid ascorbyl esters are recently emerging food, cosmetic, and pharmaceutical additives, which can be prepared in eco-friendly way by using lipases as catalysts. Since they are amphiphilic molecules which possess high free radical scavenging capacity, they can be applied as liposoluble antioxidants, as well as emulsifiers and biosurfactants. In this study, the influence of a wide range of acyl donors on ester yield in lipase-catalyzed synthesis and ester antioxidant activity was examined. Among saturated acyl donors, higher yields and antioxidant activities of esters were achieved when short chain fatty acids were used. Oleic acid gave the highest yield overall and its ester exhibited high antioxidant activity. Optimization of experimental factors showed that the highest conversion (60.5%) in acetone was achieved with 5 g L(-1) of lipase, 50 mM of vitamin C, ten-fold molar excess of oleic acid, and 0.7 mL L(-1) of initial water. Obtained results showed that even short and medium chain ascorbyl esters could be synthesized with high yields and retained (or even exceeded) free radical scavenging capacity of L-ascorbic acid, indicating prospects of broadening their application in emulsions and liposomes. This article is protected by copyright. All rights reserved.
Authors:
Marija Stojanović; Milica Carević; Mladen Mihailović; Dušan Veličković; Aleksandra Dimitrijević; Nenad Milosavić; Dejan Bezbradica
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-15
Journal Detail:
Title:  Biotechnology and applied biochemistry     Volume:  -     ISSN:  1470-8744     ISO Abbreviation:  Biotechnol. Appl. Biochem.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8609465     Medline TA:  Biotechnol Appl Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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