| Influence of fatty acid absorption on bidirectional release of immunoglobulin A into intestinal lumen and intestinal lymph in rats. | |
| | |
MedLine Citation:
|
PMID: 8125532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Effects of absorption of long and middle chain fatty acids on IgA secretion into the intestinal lumen and intestinal lymph and the factors which evoke changes in IgA secretion during the absorptive process were examined in rat small intestine. Bidirectional secretion of IgA from the intestinal mucosa into the intestinal lumen and intestinal lymph was continuously observed in the control condition. Perfusion of oleic acid (a long-chain fatty acid) micelle into the jejunal loop induced a significant increase in IgA output into the intestinal lymph. In contrast, lymphatic output of IgA was significantly decreased when oleic acid micelle was administered intraduodenally. Absorption of octanoic acid, a middle-chain fatty acid, did not produce any significant changes in IgA output into either direction. CR1505, a CCK-receptor antagonist, significantly attenuated the oleic acid-induced increase in IgA secretion into the intestinal lumen, but did not affect the oleic acid-induced decrease in lymphatic IgA secretion. Pluronic L-81, an inhibitor of chylomicron formation and secretion, significantly attenuated the decrease in IgA output into the intestinal lymph during oleic acid absorption without affecting the luminal IgA output. The rate of release of IgA into the intestinal lumen is stimulated by absorption of long-chain fatty acids possibly through the influence of locally released CCK, while the transport process of IgA into lymphatics is controlled by a different mechanism which is closely correlated with the intracellular formation and secretion of chylomicron. |
| | |
Authors:
|
H Imaeda; S Miura; H Serizawa; K Toda; N Ohkubo; H Kimura; M Yoshioka; M Tsuchiya; P Tso |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Immunology letters Volume: 38 ISSN: 0165-2478 ISO Abbreviation: Immunol. Lett. Publication Date: 1993 Nov |
Date Detail:
|
Created Date: 1994-04-14 Completed Date: 1994-04-14 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7910006 Medline TA: Immunol Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 253-8 Citation Subset: IM |
Affiliation:
|
Department of Medicine, School of Medicine, Keio University, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cholecystokinin / antagonists & inhibitors Fatty Acids / metabolism* Immunoglobulin A, Secretory / metabolism* Intestinal Absorption / immunology Intestines / immunology* Lymph / immunology* Male Micelles Poloxalene / pharmacology Proglumide / analogs & derivatives, pharmacology Rats Rats, Wistar |
| Grant Support | |
ID/Acronym/Agency:
|
1P01 DK 43785/DK/NIDDK NIH HHS; DK 32288/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 0/Immunoglobulin A, Secretory; 0/Micelles; 107097-80-3/loxiglumide; 6620-60-6/Proglumide; 9003-11-6/Poloxalene; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Age-related changes in interleukin production in BALB/cNNia and SJL/J mice and their modification af...
Next Document: Lung and HIV infection with special reference to tuberculosis: preliminary report on 20 HIV-1 seropo...