Document Detail


Influence of experimentally induced anxiety on gastric sensorimotor function in humans.
MedLine Citation:
PMID:  16285945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & AIMS: Unexplained dyspeptic symptoms are associated with changes in gastric sensorimotor function and several psychopathologic dimensions, including anxiety. It is unclear whether this reflects common predisposition or a causal relationship. The aim of this study was to investigate whether experimentally induced anxiety would alter gastric sensorimotor function in health. METHODS: Fourteen subjects underwent a gastric barostat study to assess gastric sensitivity and accommodation. Eighteen subjects underwent a 10-minute satiety drinking test (30 mL/min) with registration of epigastric symptoms on a visual analogue scale (VAS) at 2-minute intervals. Emotional context was modulated for 10 minutes at the start of each experiment by combined projection of validated facial expressions and an audiotape recalling a neutral or an anxious autobiographical experience. Anxiety levels were assessed using a VAS and the Spielberger State-Trait Anxiety Inventory (STAI). RESULTS: VAS and STAI scores confirmed efficacy of anxiety induction. During the anxiety condition, gastric compliance was significantly decreased (57 +/- 5 vs 40 +/- 5 mL/mm Hg; P < .01). Intraballoon pressures inducing discomfort during gastric distention were not altered, but the corresponding volume (630 +/- 47 vs 489 +/- 39 mL; P < .005) was significantly lower. Meal-induced relaxation was inhibited during the anxiety condition and this persisted for the 60-minute measurement (157 +/- 29 vs 100 +/- 24 mL; P < .05). During the satiety drinking test, the anxiety condition was associated with significantly higher scores for satiety, fullness, and bloating. CONCLUSIONS: Experimentally induced anxiety alters gastric sensorimotor function, suggesting that psychological factors may play a causal role in the pathogenesis of some dyspeptic symptoms and mechanisms.
Authors:
Brecht Geeraerts; Joris Vandenberghe; Lukas Van Oudenhove; Lloyd J Gregory; Quasim Aziz; Patrick Dupont; Koen Demyttenaere; Jozef Janssens; Jan Tack
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  129     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-15     Completed Date:  2006-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1437-44     Citation Subset:  AIM; IM    
Affiliation:
Center for Gastroenterological Research, Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anxiety / physiopathology*
Dyspepsia / etiology,  physiopathology*,  psychology*
Eating
Fasting / physiology,  psychology
Female
Gastric Emptying / physiology
Humans
Male
Motor Neurons / physiology
Neurons, Afferent / physiology
Pressure
Stomach / innervation*,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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