Document Detail

Influence of experimentally induced anxiety on gastric sensorimotor function in humans.
MedLine Citation:
PMID:  16285945     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Unexplained dyspeptic symptoms are associated with changes in gastric sensorimotor function and several psychopathologic dimensions, including anxiety. It is unclear whether this reflects common predisposition or a causal relationship. The aim of this study was to investigate whether experimentally induced anxiety would alter gastric sensorimotor function in health. METHODS: Fourteen subjects underwent a gastric barostat study to assess gastric sensitivity and accommodation. Eighteen subjects underwent a 10-minute satiety drinking test (30 mL/min) with registration of epigastric symptoms on a visual analogue scale (VAS) at 2-minute intervals. Emotional context was modulated for 10 minutes at the start of each experiment by combined projection of validated facial expressions and an audiotape recalling a neutral or an anxious autobiographical experience. Anxiety levels were assessed using a VAS and the Spielberger State-Trait Anxiety Inventory (STAI). RESULTS: VAS and STAI scores confirmed efficacy of anxiety induction. During the anxiety condition, gastric compliance was significantly decreased (57 +/- 5 vs 40 +/- 5 mL/mm Hg; P < .01). Intraballoon pressures inducing discomfort during gastric distention were not altered, but the corresponding volume (630 +/- 47 vs 489 +/- 39 mL; P < .005) was significantly lower. Meal-induced relaxation was inhibited during the anxiety condition and this persisted for the 60-minute measurement (157 +/- 29 vs 100 +/- 24 mL; P < .05). During the satiety drinking test, the anxiety condition was associated with significantly higher scores for satiety, fullness, and bloating. CONCLUSIONS: Experimentally induced anxiety alters gastric sensorimotor function, suggesting that psychological factors may play a causal role in the pathogenesis of some dyspeptic symptoms and mechanisms.
Brecht Geeraerts; Joris Vandenberghe; Lukas Van Oudenhove; Lloyd J Gregory; Quasim Aziz; Patrick Dupont; Koen Demyttenaere; Jozef Janssens; Jan Tack
Related Documents :
15570135 - The role of regular physical activity in preeclampsia prevention.
10593665 - Effects of pregnancy and chronic exercise on maternal cardiac structure and function.
22726625 - Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic ac...
21846165 - Effects of acute carbohydrate supplementation on endurance performance: a meta-analysis.
18468745 - Fatigue-related changes in stance leg mechanics during sidestep cutting maneuvers.
23528515 - Exercise reduces angiotensin ii responses in rat femoral veins.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  129     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-15     Completed Date:  2006-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1437-44     Citation Subset:  AIM; IM    
Center for Gastroenterological Research, Leuven, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anxiety / physiopathology*
Dyspepsia / etiology,  physiopathology*,  psychology*
Fasting / physiology,  psychology
Gastric Emptying / physiology
Motor Neurons / physiology
Neurons, Afferent / physiology
Stomach / innervation*,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of peptide YY3-36 on food intake in humans.
Next Document:  Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol sy...