Document Detail

Influence of exercise training on leptin levels in patients with stable coronary artery disease: A pilot study.
MedLine Citation:
PMID:  20865678     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was designed to examine the influence of exercise training on leptin levels in patients with stable coronary artery disease (CAD).
METHODS: Sixty-four male patients, mean age 55.6 ± 6.0 years, were randomized either to six weeks of aerobic training, three times a week, at 60-80% of maximal heart rate (training group, Ex, n = 32) or to a control group (n = 32). Exercise stress test was performed and body mass index (BMI), waist-to-hip ratio (WHR), waist circumference and plasma leptin levels were measured at the beginning and end of the study.
RESULTS: Physical capacity increased significantly only in Ex patients (max workload in METs from 7.7 ± 1.4 to 8.2 ± 1.4, p < 0.05). There were no significant differences between initial and final results in either group in terms of BMI, WHR or waist circumference. Although, at the end of the study, leptin levels did not change in Ex patients (6.7 ± 3.2 vs 6.9 ± 3.6 ng/mL, NS), they did increase significantly in the control group (8.0 ± 4.0 vs 9.3 ± 5.2 ng/mL, p < 0.02).
CONCLUSIONS: A short period of exercise training in CAD patients improved their physical capacity, but did not influence BMI, WHR and waist circumference. Exercise training prevented an increase in leptin levels during the study period.
Magdalena Kosydar-Piechna; Maria Bilińska; Jadwiga Janas; Ryszard Piotrowicz
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiology journal     Volume:  17     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-24     Completed Date:  2011-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  477-81     Citation Subset:  IM    
Department of Cardiac Rehabilitation and Noninvasive Electrocardiology, Institute of Cardiology, Warsaw, Poland.
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MeSH Terms
Adipose Tissue / physiology
Body Mass Index
Coronary Artery Disease / blood*,  therapy*
Exercise / physiology*
Exercise Test
Exercise Therapy / methods*
Leptin / blood*
Middle Aged
Pilot Projects
Waist-Hip Ratio
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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