Document Detail

Influence of exercise training on cardiac baroreflex sensitivity in patients with COPD.
MedLine Citation:
PMID:  15065828     Owner:  NLM     Status:  MEDLINE    
Decreased spontaneous cardiac baroreflex sensitivity (BRS), which could lead to the onset of cardiovascular events, has been demonstrated in chronic obstructive pulmonary disease patients. This study evaluates the effects of an exercise training programme on BRS. Twenty-one chronic obstructive pulmonary disease patients (mean+/-SD age 62+/-9 yrs; forced expiratory volume in one second 43.6+/-18.1% of the predicted value) with mild hypoxaemia (arterial oxygen tension 8.96+/-1.18 kPa) were compared to 18 healthy age-matched subjects. BRS was calculated as the slope of the baroreflex sequences between spontaneous changes in systolic blood pressure and subsequent consecutive relative risk deviation length, and was measured in the supine position and following head-up tilt for sympathetic stimulation. Pulmonary function test results and blood gas levels, measured only in patients, did not change after the training programme. Exercise training increased the maximal sustained workload (16.5%) and peak oxygen consumption (20.5%). Before training, BRS was lower in patients than in controls (2.7+/-1.5 versus 7.8+/-4.9 ms x mmHg(-1)) and tilting induced a smaller reduction in BRS (13 versus 34%). After training, BRS increased to 3.4+/-2.6 ms x mmHg(-1) in patients but remained lower than in controls. The response to the tilt test remained unchanged after training. It is concluded that, in chronic obstructive pulmonary disease patients, exercise training is associated with a gain in spontaneous baroreflex sensitivity, reflecting cardiovascular benefits.
F Costes; F Roche; V Pichot; J M Vergnon; M Garet; J C Barthelemy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  23     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-06-17     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  396-401     Citation Subset:  IM    
Cardiorespiratory Function Test Laboratory-GIP Exercice, and Dept of Pneumology and Thoracic Oncology, University Hospital, Saint-Etienne, France.
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MeSH Terms
Baroreflex / physiology*
Blood Pressure / physiology
Case-Control Studies
Exercise Test
Exercise Therapy
Exercise Tolerance
Heart / innervation*
Middle Aged
Physical Endurance
Pulmonary Disease, Chronic Obstructive / physiopathology,  rehabilitation*
Respiratory Function Tests
Tilt-Table Test

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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