Document Detail

Influence of exercise on serotonergic neuromodulation in the brain.
MedLine Citation:
PMID:  11310929     Owner:  NLM     Status:  MEDLINE    
Implications of exercise on serotonergic neuromodulation in the brain have been investigated in two studies. Acute paroxetine (selective serotonin (5-HT) reuptake inhibitor) administration to endurance athletes, who performed a cycle ergometer test to exhaustion at moderate intensity, reduced time to exhaustion and post exercise cognitive performance in comparison to trials with placebo or BCAA administration. Furthermore, during a 3-week moderate endurance training of sedentary males basaline values of Bmax of 5-HT transporters (5-HTT) and 5-HT2A receptors (5-HT(2A)R) on isolated platelet membranes increased while plasma prolactin (PRL) concentrations decreased as well as mood and physical efficiency improved. In contrast, after an excessive training program over four weeks, well-trained endurance athletes showed no change of Bmax of 5-HTT, but a decline of 5-HT(2A)R density and an increase in basal plasma PRL concentration. Mood was impaired and central fatigue increased. Thus, the impact of exercise on 5-HT neurotransmission may depend on training state of athletes and extent of exertion. The theoretical background of the implication of exercise and the effect of long lasting exhaustive exercise in athletes on mental and physical efficiency or central fatigue are evaluated. The significance of the primary disturbance of central neuromodulation and dysfunction of 5-HTT, 5-HT receptor subtypes and the phosphoinositol signal transduction as well as the limited modulation capacity of the 5-HT system in overstrain are also addressed.
H Weicker; H K Strüder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Amino acids     Volume:  20     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  2001  
Date Detail:
Created Date:  2001-04-19     Completed Date:  2001-07-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  35-47     Citation Subset:  IM    
Department of Sports Medicine, University of Heidelberg, Federal Republic of Germany.
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MeSH Terms
Amino Acids, Branched-Chain / metabolism
Binding Sites
Blood Platelets / metabolism
Brain / metabolism*
Cell Nucleus / metabolism
Dose-Response Relationship, Drug
Models, Biological
Neurons / physiology
Paroxetine / pharmacology
Prolactin / blood
Protein Binding
Receptor, Serotonin, 5-HT2A
Receptors, Serotonin / metabolism
Serotonin / metabolism*
Serotonin Uptake Inhibitors / pharmacology
Signal Transduction
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/Receptor, Serotonin, 5-HT2A; 0/Receptors, Serotonin; 0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin; 61869-08-7/Paroxetine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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