| Influence of exercise mode and osteogenic index on bone biomarker responses during short-term physical training. | |
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MedLine Citation:
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PMID: 19520194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prescribing exercise based on intensity, frequency, and duration of loading may maximize osteogenic responses in bone, but a model of the osteogenic potential of exercise has not been established in humans. In rodents, an osteogenic index (OI) has been used to predict the osteogenic potential of exercise. The current study sought to determine whether aerobic, resistance, or combined aerobic and resistance exercise programs conducted over eight weeks and compared to a control group could produce changes in biochemical markers of bone turnover indicative of bone formation. We further sought to determine whether an OI could be calculated for each of these programs that would reflect observed biochemical changes. We collected serum biomarkers [bone-specific alkaline phosphatase (BAP), osteocalcin, tartrate-resistant acid phosphatase (TRAP), C-terminal telopeptide fragment of type I collagen (CTx), deoxypyridinoline (DPD), 25-hydroxy vitamin D (25(OH)D), and parathyroid hormone (PTH)] in 56 women (20.3+/-1.8 years) before, during and after eight weeks of training. We also measured bone mineral density (BMD) at regional areas of interest using DXA and pQCT. Biomarkers of bone formation (BAP and osteocalcin) increased in the Resistance and Combined groups (p<0.05), while biomarkers of bone resorption (TRAP and DPD) decreased and increased, respectively, after training (p<0.05) in all groups. Small changes in volumetric and areal BMD (p<0.05) were observed in the distal tibia in the Aerobic and Combined groups, respectively. Mean weekly OIs were 16.0+/-1.9, 20.6+/-2.2, and 36.9+/-5.2 for the Resistance, Aerobic, and Combined groups, respectively. The calculated osteogenic potential of our programs did not correlate with the observed changes in biomarkers of bone turnover. The results of the present study demonstrate that participation in an eight week physical training program that incorporates a resistance component by previously inactive young women results in alterations in biomarkers of bone remodeling indicative of increased formation without substantial alterations in markers of resorption. |
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Authors:
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Mark E Lester; Maria L Urso; Rachel K Evans; Joseph R Pierce; Barry A Spiering; Carl M Maresh; Disa L Hatfield; William J Kraemer; Bradley C Nindl |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-06-09 |
Journal Detail:
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Title: Bone Volume: 45 ISSN: 1873-2763 ISO Abbreviation: Bone Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-08-24 Completed Date: 2009-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504048 Medline TA: Bone Country: United States |
Other Details:
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Languages: eng Pagination: 768-76 Citation Subset: IM |
Affiliation:
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Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Building 42, Kansas Street, Natick, MA 01760, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Acid Phosphatase / blood Alkaline Phosphatase / metabolism Amino Acids / blood Anthropometry Biological Markers / metabolism Bone and Bones / enzymology, metabolism*, radiography Collagen Type I / blood Diet Exercise / physiology* Female Humans Isoenzymes / blood Osteocalcin / blood Osteogenesis / physiology* Parathyroid Hormone / blood Peptides / blood Physical Fitness / physiology* Time Factors Tomography, X-Ray Computed Vitamin D / analogs & derivatives, blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Biological Markers; 0/Collagen Type I; 0/Isoenzymes; 0/Parathyroid Hormone; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 104982-03-8/Osteocalcin; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; 90032-33-0/deoxypyridinoline; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC 3.1.3.1/Alkaline Phosphatase; EC 3.1.3.2/Acid Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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