Document Detail


Influence of exercise-induced plasma volume changes on the interpretation of biochemical data following high-intensity exercise.
MedLine Citation:
PMID:  9262885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the effects that exercise-induced plasma volume changes (PVCs) have on the interpretation of biochemical and hormonal parameters in the blood of athletes after high-intensity exercise. It was hypothesized that two unrelated high-intensity exercise protocols, performed by two separate subject groups each using different exercise modes, would result in similar percentage changes in plasma volume (% delta PV). It was further hypothesized that the % delta PV, measured in both protocols, would comparably influence the interpretation of biochemical variables measured following exercise. DESIGN: An experimental before-after trial on volunteers was performed. Two different exercise modes employing two different high-intensity acute exercise protocols were investigated. Eight male swimmers performed an interval training session (ITS) consisting of 15 x 100-m freestyle efforts at 95% of their maximal exercise intensity, and eight male runners performed a multistage discontinuous treadmill test (MSD) to volitional exhaustion. SETTING: The Human Performance Laboratory at the Department of Human Movement at the University of Western Australia. MAIN OUTCOME MEASURES: Blood samples obtained before, immediately after, and 30, 60, and 120 min during recovery were analyzed for plasma volume changes, urea, uric acid, creatinine, albumin, calcium, iron, transferrin, testosterone, cortisol, and sex hormone-binding globulin (SHBG). MAIN RESULTS: The ITS and MSD protocols produced similar and significant alterations (p < 0.01) in plasma volume. Both protocols also elicited significant fluctuations (p < 0.01) in the concentration of most of the parameters measured (excluding iron). When albumin, transferrin, testosterone, and SHBG values were adjusted for the significant % delta PV, their concentrations did not change over the experimental period, suggesting that the changes in measured concentration of these parameters may be, in part, due to changes in plasma volume. However, urea, uric acid, creatinine, calcium, and cortisol, when corrected for % delta PVC, still demonstrated significant changes (p < 0.01). CONCLUSIONS: It is recommended, when sampling biochemical and hormonal parameters in blood following an acute bout of exercise, that corrections for PVCs should be conducted. Apparent changes in blood solutes may reflect PVCs. PVCs should be taken into consideration when interpreting results regardless of exercise protocol and exercise mode performed.
Authors:
S Kargotich; C Goodman; D Keast; R W Fry; P Garcia-Webb; P M Crawford; A R Morton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine     Volume:  7     ISSN:  1050-642X     ISO Abbreviation:  Clin J Sport Med     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-10-02     Completed Date:  1997-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9103300     Medline TA:  Clin J Sport Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Affiliation:
Department of Microbiology, University of Western Australia, Nedlands.
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MeSH Terms
Descriptor/Qualifier:
Blood Chemical Analysis*
Exercise / physiology*
Heart Rate / physiology
Humans
Lactic Acid / blood
Male
Physical Education and Training / methods
Plasma Volume*
Running / physiology
Swimming / physiology
Chemical
Reg. No./Substance:
50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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