Document Detail


Influence of exercise on the circulating levels and macrophage production of IL-1beta and IFNgamma affected by metabolic syndrome: an obese Zucker rat experimental animal model.
MedLine Citation:
PMID:  19688220     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regular physical activity is recognized as a non-pharmacological treatment of genetic obesity and type-II diabetes, and based on the "anti-inflammatory" effects of exercise, it has been also proposed for improving the "chronic low-grade inflammation" in metabolic syndrome (MS). The aim of the present work was to evaluate the effects of an habitual exercise program (running, 5 days/week for 35 min at 35 cm/s for 14 weeks) and of a bout of acute exercise (running, for 35 min at 35 cm/s) on MS-associated disorders in the pro-inflammatory cytokines IL-1beta and IFNgamma. The study was carried out on obese Zucker rats (fa/fa). The obese rats presented higher circulating concentrations and constitutive macrophage production (in the absence of antigenic stimulus) of IL-1beta (but not of IFNgamma). But their production of both IL-1beta and IFNgamma by lipopolysaccharide (LPS)-stimulated macrophages was lower than that of the control lean rats. Our protocol of exercise training did not modify the circulating concentration and constitutive macrophage release of either IL-1beta or IFNgamma in the obese rats, but increased the production of both cytokines by LPS-stimulated macrophages. The single bout of acute exercise only increased the release of IL-1beta by the LPS-stimulated macrophages from obese rats, in both sedentary and trained animals. The results indicated that: (1) circulating levels and constitutive production of IL-1beta by macrophages are deregulated in rats with MS, and (2) IL-1beta and IFNgamma production by macrophages in response to antigenic stimulus (LPS) is impaired in the obese animals, and this MS-associated disorder is improved by the program of habitual exercise training.
Authors:
L Martin-Cordero; J J Garcia; E Giraldo; M De la Fuente; R Manso; E Ortega
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-18
Journal Detail:
Title:  European journal of applied physiology     Volume:  107     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-27     Completed Date:  2010-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  535-43     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Sciences, University of Extremadura, 06071 Badajoz, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Exercise Test / veterinary
Interferon-gamma* / blood,  metabolism
Interleukin-1beta* / blood,  metabolism
Lipopolysaccharides / pharmacology
Macrophages, Peritoneal / drug effects,  metabolism*
Male
Metabolic Syndrome X / blood*,  metabolism*,  pathology
Models, Animal
Obesity / blood,  metabolism,  pathology
Physical Conditioning, Animal / physiology*
Rats
Rats, Zucker
Thinness / blood,  metabolism,  pathology
Chemical
Reg. No./Substance:
0/Interleukin-1beta; 0/Lipopolysaccharides; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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