Document Detail

Influence of exercise and CO2 on breathing pattern in patients with chronic obstructive lung disease (COLD).
MedLine Citation:
PMID:  3129301     Owner:  NLM     Status:  MEDLINE    
In ten eucapnic patients with chronic obstructive lung disease (COLD) we evaluated the breathing pattern during induced progressive hypercapnia (CO2 rebreathing) and progressive exercise on an ergometric bicycle (30 W/3 min). The time and volume components of the respiratory cycle were measured breath by breath. When compared to hypercapnia, the increase in ventilation (VE) during exercise was associated with a smaller increase in tidal volume (VT) and a greater increase in respiratory frequency (fR). Plots of tidal volume (VT) against both inspiratory time (TI) and expiratory time (TE) showed a greater decrease in both TI and TE during exercise than with hypercapnia. Analysis of VE in terms of flow (VT/TI) and timing (TI/TT) showed VE to increase by a similar increase to that in VT/TI during both exercise and hypercapnia, while TI/TT did not change significantly. When the patients were matched for a given VE (28 l.min-1), exercise induced a smaller increase in VT (p less than 0.05), a greater increase in fR (p less than 0.025); TI (p less than 0.025) and TE (p less than 0.01) were found to be smaller during exercise than hypercapnia. The change in the off-switch mechanism during exercise and hypercapnia could account for our results.
G Scano; F Gigliotti; A van Meerhaeghe; A De Coster; R Sergysels
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  1     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-05-31     Completed Date:  1988-05-31     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM; S    
Clinica Medica III, Università di Firenze, Italy.
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MeSH Terms
Carbon Dioxide / physiology*
Hypercapnia / physiopathology
Lung Diseases, Obstructive / physiopathology*
Middle Aged
Physical Exertion*
Pulmonary Ventilation
Tidal Volume
Reg. No./Substance:
124-38-9/Carbon Dioxide

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