Document Detail

Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients.
MedLine Citation:
PMID:  15069434     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the influence of ethnic origin on the incidence of keratoconus and the association of atopic diseases in patients with keratoconus. METHODS: Retrospective study of new patients referred to Dewsbury District General Hospital and diagnosed with keratoconus in a 6-year period between 1994 and 2000. The ethnic origin of the patient was defined as white, Asian, or other. Incidence was calculated from the catchment population of 176 774 (82% white people, 17% Asians, 1% others). t-Test, confidence intervals and chi2 tests were used to show statistical significance. RESULTS: A total of 74 cases of keratoconus were diagnosed over this period. Of these patients 29 (39%) were white and 45 (61%) were Asian. This equated to an incidence of keratoconus of 25 per 100 000 (1 in 4000) per year for Asians, compared with 3.3 per 100 000 (1 in 30 000) per year for white people (P<0.001). Asians presented significantly younger than white patients. The incidence of atopic disease was found to be significantly higher in white compared to Asian keratoconic patients. CONCLUSIONS: Asians were significantly more likely to present with keratoconus. The Asian patients were mostly of Northern Pakistani origin. This community has a tradition of consanguineous, especially first-cousin marriages. The higher incidence in this population was highly suggestive of a genetic factor being significant in the aetiology. The incidence was higher than revealed by previous studies. Atopic disease was significantly less common in Asians compared to white people, supporting the theory of a different aetiology in these patients.
T Georgiou; C L Funnell; A Cassels-Brown; R O'Conor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Eye (London, England)     Volume:  18     ISSN:  0950-222X     ISO Abbreviation:  Eye (Lond)     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-07     Completed Date:  2004-08-12     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  379-83     Citation Subset:  IM    
Dewsbury District Hospital, Yorkshire, UK.
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MeSH Terms
Age Factors
Asian Continental Ancestry Group / statistics & numerical data*
England / epidemiology
European Continental Ancestry Group / statistics & numerical data*
Hypersensitivity, Immediate / complications,  ethnology*
Keratoconus / complications,  ethnology*
Retrospective Studies
Comment In:
Eye (Lond). 2005 Aug;19(8):924-5; author reply 925-6   [PMID:  15389278 ]

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