Document Detail

Influence of ethanol upon the introduction of tyrosine aminotransferase in liver, upon the NAD content in liver and brain, and upon the activity of glutamate oxalate aminotransferase and glutamate pyruvate aminotransferase in the serum of rats.
MedLine Citation:
PMID:  2858429     Owner:  NLM     Status:  MEDLINE    
The influence of ethanol, tryptophan, nicotinamide and methionine upon the activity of glutamate oxalate aminotransferase and glutamate pyruvate aminotransferase in serum as well as the induction of tyrosine aminotransferase in the liver, and of NAD+ + NADH in liver and brain are described. After oral application of 6 g/kg ethanol, the activities of the examined enzymes and the concentrations of NAD+ + NADH in the brain as well as in the liver did not change over a period of 8 hr. Administration of L-methionine lead--as is the case with DL-tryptophan--to a decrease of the NAD+ + NADH-concentration in the brain. A simultaneous application of nicotinamide, DL-tryptophan, L-methionine of l-methylnicotinamide together with ethanol caused a significant increase of the tyrosine aminotransferase induction in adrenalectomized animals. Ethanol reduced the activity of the ADPR transferase in the nuclei of rat liver cells.
H Kröger; R Grätz; H Grahn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  16     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
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MeSH Terms
Alanine Transaminase / blood*
Aspartate Aminotransferases / blood*
Brain Chemistry / drug effects*
Ethanol / pharmacology*
Liver / enzymology*,  metabolism
Methionine / metabolism,  pharmacology
NAD / metabolism*
Niacinamide / analogs & derivatives,  pharmacology
Rats, Inbred Strains
Tryptophan / pharmacology
Tyrosine Transaminase / metabolism*
Reg. No./Substance:
3106-60-3/N(1)-methylnicotinamide; 53-84-9/NAD; 63-68-3/Methionine; 64-17-5/Ethanol; 73-22-3/Tryptophan; 98-92-0/Niacinamide; EC Aminotransferases; EC Transaminase; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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