Document Detail


Influence of ethanol on systemic and pulmonary hemodynamics in anesthetized dogs.
MedLine Citation:
PMID:  6624504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immediate circulatory reactions to acute intragastric ethanol administration were studied by a catheterization technique in spontaneously breathing dogs. Diluted ethanol was given in a dosage of 1 g/kg in test group I (n = 11), and 2/kg in group II (n = 10). The control group (m = 14) received only water. The highest blood ethanol concentration was 0.90 +/- 0.07 mg/ml (mean +/- SE) in group I, and 1.97 +/- 0.10 mg/ml in group II. Heart rate and cardiac output increased (p less than 0.,001), but stroke volume, mean aortic blood pressure and right atrial blood pressure remained practically unchanged. Systemic vascular resistance decreased. Mean pulmonary arterial blood pressure increased markedly in both test groups (p less than 0.001) while pulmonary arterial wedge pressure did not change. The pulmonary arterial resistance increased (p less than 0.01). Changes in respiratory rate or volume and arterial pO2 were negligible in group I, but respiratory minute volume decreased in group II. In conclusion, ethanol in concentrations 0.5 to 2.0 mg/ml increased resistance in the pulmonary arterial tree, indicating pulmonary arterial vasoconstriction, but reduced systemic vascular resistance, thus putting a concept of peripheral vasodilation in favour.
Authors:
R Kettunen; J Timisjärvi; P Saukko; M Koskela
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  118     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Circulation / drug effects
Blood Pressure / drug effects
Blood Volume / drug effects
Cardiac Output / drug effects
Dogs
Ethanol / pharmacology*
Female
Heart Rate / drug effects
Hemodynamics / drug effects*
Lung / physiology*
Male
Respiration / drug effects
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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