| Influence of estrogen on aortic stiffness and endothelial function in female rats. | |
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MedLine Citation:
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PMID: 11788396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mechanisms underlying cardioprotective properties of estrogens are not fully understood. We evaluated effects of ovariectomy and estrogen replacement on arterial distensibility and endothelial function in rats. Sprague-Dawley rats were sham operated (Sham) or ovariectomized and treated with 17beta-estradiol (OVX-E(2)) or vehicle (OVX) for 3 wk. Anesthetized rats were instrumented for measurement of central and peripheral arterial blood pressures and carotid and hindquarters blood flows. Arterial distensibility was evaluated in anesthetized rats on the basis of changes in thoracoabdominal pressure pulse wave velocity (PWV). PWV was calculated as the distance between the two central and peripheral cannula tips divided by transit time. Ovariectomy significantly reduced PWV (390 +/- 19 and 472 +/- 42 cm/s in OVX and Sham, respectively). Estrogen treatment completely normalized PWV (490 +/- 37 cm/s). Estrogen-treated rats were associated with left ventricular hypertrophy and increased pulse pressure. Resting hemodynamic parameters were similar in all groups. Estrogen replacement significantly potentiated bradykinin vasodilatory responses in the hindlimb, but not in the carotid vascular bed. Hemodynamic responses to sodium nitroprusside and ANG II were similar in all groups. In conclusion, our results demonstrate for the first time that aortic stiffness determined by PWV is decreased in estrogen-deficient rats. Estrogen treatment increases aortic stiffness and potentiates endothelial vasodilator function in the hindquarters, but not in the carotid vascular bed, suggesting a regional heterogeneity in the modulatory influence of estrogen on vasomotor function. |
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Authors:
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Rabelais Tatchum-Talom; Céline Martel; André Marette |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 282 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-14 Completed Date: 2002-02-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H491-8 Citation Subset: IM |
Affiliation:
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Department of Physiology and Lipid Research Unit, Laval University Hospital Research Center, Ste-Foy, Quebec, Canada G1V 4G2. rabelais.tatchum@crchul.ulaval.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Angiotensin II / pharmacology Animals Aorta / drug effects*, physiology* Blood Pressure / drug effects Bradykinin / pharmacology Carotid Arteries / physiology Elasticity Endothelium, Vascular / drug effects*, physiology* Estradiol / pharmacology* Female Heart Rate / drug effects Nitroprusside / pharmacology Ovariectomy Rats Rats, Sprague-Dawley Vascular Resistance / drug effects Vasoconstrictor Agents / pharmacology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 0/Vasodilator Agents; 11128-99-7/Angiotensin II; 15078-28-1/Nitroprusside; 50-28-2/Estradiol; 58-82-2/Bradykinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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