Document Detail

Influence of epinephrine on the aggregation response of aspirin-treated platelets.
MedLine Citation:
PMID:  7403340     Owner:  NLM     Status:  MEDLINE    
We have evaluated the influence of epinephrine on the sensitivity of aspirin-treated platelets to aggregating agents. Concentrations of ADP, thrombin and arachidonate that caused reversible stimulation of aspirin platelets produced irreversible aggregation when the aspirin samples had been pretreated with epinephrine. The correction was not due to improvement in the ability of aspirin platelets to synthesize prostaglandins or secrete products of the release reaction. Epinephrine induced correction of refractory aspirin platelets may help to explain why aspirin is not a universally effective anti-thrombotic agent.
G H Rao; G J Johnson; J G White
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins and medicine     Volume:  5     ISSN:  0161-4630     ISO Abbreviation:  Prostaglandins Med     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7810330     Medline TA:  Prostaglandins Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-58     Citation Subset:  IM    
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MeSH Terms
Adenosine Diphosphate / pharmacology
Arachidonic Acids / metabolism,  pharmacology
Aspirin / pharmacology*
Blood Platelets / metabolism
Epinephrine / pharmacology*
Platelet Aggregation / drug effects*
Serotonin / secretion
Thrombin / pharmacology
Thromboxane B2 / metabolism
Reg. No./Substance:
0/Arachidonic Acids; 50-67-9/Serotonin; 50-78-2/Aspirin; 51-43-4/Epinephrine; 54397-85-2/Thromboxane B2; 58-64-0/Adenosine Diphosphate; EC

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