| Influence of endogenous opioids on atrial natriuretic factor release during exercise in man. | |
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MedLine Citation:
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PMID: 2555188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate to what extent opioid secretion in exercise induces the release of atrial natriuretic factor (ANF), six healthy male volunteers who were trained subjects, were submitted to two maximal exercise tests with and without (control) opioid receptor blockade by Naltrexone. Blood samples were drawn before (rest) and after exercise (post-exercise) in order to measure human ANF (alpha h ANF), beta-endorphin, plasma aldosterone concentration (PAC) plasma renin activity (PRA) and adreno-cortico trophic hormone (ATCH) by radio-immunological methods. Expired gas was collected during exercise to measure oxygen consumption. On average, the same maximal oxygen consumption (VO2max) during exercise was reached by all subjects with and without treatment. Plasma ANF level at rest slightly decreased after administration of Naltrexone; the response to physical exercise was significantly reduced by Naltrexone. There was no statistical difference between plasma levels of beta-endorphin, PRA and ACTH at rest nor in the post-exercise situation under the influence of Naltrexone. The PAC increased significantly at rest after Naltrexone administration but there was no statistical difference between both values after exercise. These data demonstrate that: (1) ANF secretion during exercise is influenced by the level of beta-endorphin in the plasma; (2) the possible inhibitory role of ANF on aldosterone secretion during exercise is probably over-ruled by the increase in plasma ACTH and PRA. |
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Authors:
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F Louisy; C Y Guezennec; M Lartigue; J C Aldigier; F X Galen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of applied physiology and occupational physiology Volume: 59 ISSN: 0301-5548 ISO Abbreviation: Eur J Appl Physiol Occup Physiol Publication Date: 1989 |
Date Detail:
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Created Date: 1989-12-27 Completed Date: 1989-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410266 Medline TA: Eur J Appl Physiol Occup Physiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 34-8 Citation Subset: IM |
Affiliation:
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Centre d'Etude et de Recherches de Médecine Aérospatiale, Laboratoire de Physiologie Métabolique et Hormonale, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood Adult Atrial Natriuretic Factor / blood* Endorphins / blood, pharmacology, physiology* Exercise / physiology* Humans Male Naltrexone / pharmacology Receptors, Opioid / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 0/Receptors, Opioid; 16590-41-3/Naltrexone; 85637-73-6/Atrial Natriuretic Factor; 9002-60-2/Adrenocorticotropic Hormone |
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