| Influence of endogenous glutathione level on X-ray induced cell cycle delay in human lymphocytes. | |
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MedLine Citation:
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PMID: 16426421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here, induction of chromosomal aberration after X-irradiation and the pattern of cell cycle kinetics have been investigated in human lymphocytes, after exogenous addition of reduced glutathione or by depleting levels of reduced glutathione endogenously. Involvement of cell cycle regulator proteins such as p53 and p21 has been investigated to elucidate their role in induction of delay in cell cycle progression after irradiation. |
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Authors:
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S Ray; A Chatterjee |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell proliferation Volume: 39 ISSN: 0960-7722 ISO Abbreviation: Cell Prolif. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-23 Completed Date: 2006-03-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105195 Medline TA: Cell Prolif Country: England |
Other Details:
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Languages: eng Pagination: 37-47 Citation Subset: IM |
Affiliation:
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Genetics Laboratory, Department of Biotechnology and Bioinformatics, North-Eastern Hill University, Shillong, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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radiation effects* Cells, Cultured Chromosome Aberrations / radiation effects Cyclin-Dependent Kinase Inhibitor p21 / physiology* Glutathione / metabolism* Humans Lymphocytes / metabolism, radiation effects* Male Sister Chromatid Exchange Tumor Suppressor Protein p53 / physiology* X-Rays |
| Chemical | |
Reg. No./Substance:
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0/Cyclin-Dependent Kinase Inhibitor p21; 0/Tumor Suppressor Protein p53; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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