Document Detail


Influence of enalapril on the endothelial function of DOCA-salt hypertensive rats.
MedLine Citation:
PMID:  10974419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we investigated whether the correction of endothelial dysfunction can be independent of the normalization of high blood pressure levels by enalapril in deoxycorticosterone (DOCA-salt) hypertensive rats. Aorta morphology and the response of aortas with (E+) and without (E-) endothelium to noradrenaline, acetylcholine, and sodium nitroprusside were studied. DOCA-salt hypertensive and normotensive (control) rats were or were not treated with enalapril (5 mg/day/rat in the drinking fluid) for 1, 7, or 15 days. Blood pressure was measured before and after 1, 3, 7, and 15 days of enalapril treatment. Enalapril normalized the high blood pressure levels in 50% (responders) of the hypertensive rats after 3 to as many as 15 days but not after 1 day of treatment. Initial blood pressure levels were not different between responders and nonresponders. Blood pressure levels of normotensive control rats were not altered by enalapril treatment. The tunica media of aortas of DOCA-salt hypertensive rats treated or not treated with enalapril for 15 days was thicker than aortas from normotensive rats. Enalapril corrected the reduced response to acetylcholine observed in aorta from hypertensive rats from the first day of treatment. This treatment rendered aortas from normotensive control rats more sensitive (lower EC(50)) to acetylcholine without a change in the maximal responses. The responses to sodium nitroprusside, a nitric oxide donor, were unaltered in aorta E+ or E- from control and hypertensive rats before and after enalapril treatment. Enalapril did not correct the increased responses to noradrenaline observed in aorta E+ of hypertensive rats. These results suggest that the high blood pressure in DOCA-salt hypertension is not correlated with the altered response to endothelium-dependent agents (either dilator or constrictors). The endothelium-dependent vasodilation by antihypertensive agents can be corrected independently of normalization of blood pressure levels or the vascular morphology.
Authors:
V W Nunes; Z B Fortes; D Nigro; M H Carvalho; T M Zorn; R Scivoletto
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General pharmacology     Volume:  34     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-09-22     Completed Date:  2000-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  117-25     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Laboratory of Hypertension, SP, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Animals
Antihypertensive Agents / pharmacology*
Aorta, Thoracic / drug effects,  physiopathology
Blood Pressure / drug effects
Desoxycorticosterone
Dose-Response Relationship, Drug
Enalapril / pharmacology*
Endothelium, Vascular / drug effects*,  physiopathology
Hypertension / chemically induced,  drug therapy,  physiopathology*
Male
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects,  physiopathology
Nitroprusside / pharmacology
Norepinephrine / pharmacology
Potassium Chloride / administration & dosage
Rats
Rats, Wistar
Sodium Chloride / administration & dosage
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 64-85-7/Desoxycorticosterone; 7447-40-7/Potassium Chloride; 75847-73-3/Enalapril; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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