| Influence of elevated renin substrate on angiotensin II and arterial blood pressure in conscious mice. | |
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MedLine Citation:
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PMID: 15833753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present experiments were performed to determine the influence of intravenous administration of renin substrate on plasma angiotensin II levels and mean arterial blood pressure in conscious C57BL/6J mice. Mice with chronic indwelling femoral arterial and venous catheters were acutely or chronically administered intravenous doses of a synthetic peptide corresponding to the 14 amino acids on the N-terminal of angiotensinogen. A dose-dependent increase in arterial blood pressure was observed as the intravenous bolus dose of the renin substrate was increased from 0.18 to 180 nmol kg(-1) with a maximal increase in pressure of 40 +/- 3 mmHg achieved following administration of the 18 nmol kg(-1) bolus (n = 11). Additional experiments demonstrated that a sustained intravenous infusion of the renin substrate led to a long-term increase in arterial blood pressure. The continuous infusion of renin substrate at 0.05 nmol kg(-1) min(-1) for 3 days did not alter arterial blood pressure from the control level of 119 +/- 5 mmHg (n = 5); however, arterial blood pressure significantly increased to 129 +/- 6 mmHg with an infusion rate of 0.5 nmol kg(-1) min(-1) and further increased to 141 +/- 3 mmHg when the renin substrate infusion was increased to 5.0 nmol kg(-1) min(-1). Finally, the infusion of renin substrate at 5.0 nmol kg(-1) min(-1) resulted in a significant increase in plasma angiotensin II concentration from 34 +/- 6 pg ml(-1) in vehicle-infused mice to 288 +/- 109 pg ml(-1). These results demonstrate that modulation of the circulating level of angiotensinogen can alter the plasma angiotensin II level and arterial blood pressure in normal animals. |
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Authors:
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Brian C Cholewa; David L Mattson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2005-04-15 |
Journal Detail:
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Title: Experimental physiology Volume: 90 ISSN: 0958-0670 ISO Abbreviation: Exp. Physiol. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-04 Completed Date: 2005-09-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: England |
Other Details:
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Languages: eng Pagination: 607-12 Citation Subset: IM |
Affiliation:
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Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, PO Box 26509, Milwaukee, WI 53226-0509, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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blood,
metabolism* Angiotensinogen / pharmacology* Animals Blood Pressure / drug effects* Dose-Response Relationship, Drug Heart Rate / drug effects Infusions, Intravenous Male Mice Mice, Inbred C57BL Renin / blood |
| Grant Support | |
ID/Acronym/Agency:
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DK-62803/DK/NIDDK NIH HHS; HL-29587/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11002-13-4/Angiotensinogen; 11128-99-7/Angiotensin II; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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